Last update March 8, 2022

Isoxsuprine Hydrochloride

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Isoxsuprine is a vasodilator that stimulates beta-adrenergic receptors. It has been used to stop uterine contractions in threatened premature labor and in the treatment of cerebral and peripheral vascular diseases. Oral or intravenous administration 3 or 4 times a day.

Since the last update we have not found published data on its excretion in breastmilk.

The paucity of published pharmacokinetic data does not allow prediction of its possible excretion in breast milk. Its high volume of distribution would make it difficult for it to pass into breast milk.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Atosiban (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Nifedipine (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Isoxsuprine Hydrochloride in other languages or writings:

Group

Isoxsuprine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Isoxsuprine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 338 daltons
VD 1.7 - 16.2 l/Kg
pKa 9.65 -
Tmax 1 hours
1.25 - 2.2 hours

References

  1. UNILAB. Isoxsuprine (Isoxilan). Drug Summary. 2020 Full text (in our servers)
  2. Marzo A, Zava D, Coa K, Dal Bo L, Ismaili S, Tavazzi S, Cantoni V. Pharmacokinetics of isoxsuprine hydrochloride administered orally and intramuscularly to female healthy volunteers. Arzneimittelforschung. 2009;59(9):455-60. Abstract

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