Last update Jan. 19, 2022

Isoprenaline

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Isoprenaline is a sympathomimetic beta-adrenergic agonist. It increases heart rate, causes peripheral vasodilation and has bronchodilator properties. Indicated in the treatment of bradycardia and heart block, and bronchoconstriction in anesthesia. Intravenous or inhaled administration

Since the last update we have not found any published data on its excretion in breast milk.

Its pharmacokinetic data (low molecular weight, moderate protein binding) makes transfer to breast milk possible, but its very short half-life (5 minutes) makes it difficult.

Its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Depending on the clinical status of the mother, half an hour (6 T½) after finishing the administration of isoprenaline, she can breastfeed without risk to the infant.

 

 

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Isoprenaline is also known as


Isoprenaline in other languages or writings:

Tradenames

Main tradenames from several countries containing Isoprenaline in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja - low %
Molecular weight 211 daltons
Protein Binding 69 %
VD 0.2 l/Kg
pKa 9.81 -
Tmax 0.2 hours
0.1 hours

References

  1. AEMPS. Isoprenalina (Aleudrina). Ficha técnica. 2011 Full text (in our servers)
  2. Morgan DJ. Clinical pharmacokinetics of beta-agonists. Clin Pharmacokinet. 1990 Abstract

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