Last update May 21, 2020

Indapamide

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Thiazide-like diuretic.
indicated in the treatment of hypertension and for oedema associated with heart failure
Oral administration once a day.

Since the last update we have not found any published data on its excretion in breast milk.

Long-term treatment with diuretic drugs (particularly those Thiazides with long lasting effect and loop-acting drugs) may inhibit lactation, but despite some older studies, there is no scientific evidence that diuretics reduce breast milk production (Rowe 2013).
Use a lower dose as possible, especially during the first postnatal month.

Expert authors consider the use of this medication to be probably compatible during breastfeeding (Hale 2019, Briggs 2017).

Alternatives

  • Chlorothiazide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Furosemide (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Hydrochlorothiazide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Indapamide in other languages or writings:

Group

Indapamide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Indapamide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 93 %
Molecular weight 366 daltons
Protein Binding 71 - 79 %
pKa 8.85 -
Tmax 1 - 2 hours
18 (14 - 24) hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on March 17, 2022 Full text (link to original source)
  2. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. Normon. Indapamida. Ficha técnica. 2011 Full text (in our servers)
  6. Sanis. Indapamide. Drug Summary. 2011 Full text (in our servers)

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