Last update Sept. 1, 2022

Hyaluronic Acid

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Polysaccharide with a very high molecular weight which is a component of connective tissue of the organism. It is made up of a polymer of more than 20,000 chained disaccharides of D-glucuronic acid and N-acetyl-D-glucosamine. As a lubricant, it is a major component of the synovial fluid of the joints, humor vitreo and subcutaneous tissue. It is used as a topical preparation in the eye, skin and wounds and for infiltrations in the eyes and joints for lubricating, healing, cosmetic and surgical purposes.

At latest update no published data on excretion into breast milk were found.

With a high molecular weight, excretion into breast milk seems unlikely.

Because of a null oral bioavailabilityl (Maccari 2016), the absorption to the infant's plasma from ingested breast milk is greatly impeded.

In addition, it is a natural component of the human body that is also found in breast milk (Maccari 2016, Hill 2013)

Alternatives

We do not have alternatives for Hyaluronic Acid since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Hyaluronic Acid is also known as


Hyaluronic Acid in other languages or writings:

Groups

Hyaluronic Acid belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Hyaluronic Acid in its composition:

List of 95 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 777 x n = 500.000 - 20.000.000 daltons

References

  1. Maccari F, Mantovani V, Gabrielli O, Carlucci A, Zampini L, Galeazzi T, Galeotti F, Coppa GV, Volpi N. Metabolic fate of milk glycosaminoglycans in breastfed and formula fed newborns. Glycoconj J. 2016 Abstract
  2. du Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther. 2014 Abstract
  3. Hill DR, Rho HK, Kessler SP, Amin R, Homer CR, McDonald C, Cowman MK, de la Motte CA. Human milk hyaluronan enhances innate defense of the intestinal epithelium. J Biol Chem. 2013 Oct 4;288(40):29090-104. Abstract Full text (link to original source)
  4. Monfort J, Benito P. El ácido hialurónico en el tratamiento de la artrosis. [Hyaluronic acid in the treatment of osteoarthritis]. Reumatol Clin. 2006 Abstract Full text (in our servers)
  5. Dahl LB, Dahl IM, Engström-Laurent A, Granath K. Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann Rheum Dis. 1985 Abstract Full text (link to original source) Full text (in our servers)

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