Last update July 22, 2025

Guarana

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

The seed of this climbing plant, native to the Amazon and widespread throughout South America, is used. It contains alkaloids, xanthines (caffeine 1 to 7%, theobromine 0.01 to 0.2%, and theophylline 0.01 to 0.3%) and tannins. Attributed properties: nervous system stimulant, diuretic, bronchodilator. Indications approved by the European Medicines Agency (EMA 2013): states of fatigue and weakness. Component of many brands of energy drinks, infusions, capsules and tablets for energising and slimming purposes. (Schimpl 2013, Woods 2012)

At the date of the last update, we found no published data on its excretion in breast milk, but it is known that xanthines are excreted in breast milk, so it is not advisable to exceed the equivalent of 300 mg of caffeine per day during breastfeeding.

Guarana seeds contain four times more caffeine than coffee beans. (Moustakas 2015)

Inappropriate or excessive consumption can cause hypertension (Jalili 2013, Moaddeb 2011, Arditti 2002) and has led to cases of convulsions and cardiac arrhythmias due to intoxication. (Ciszowski 2014, Pendleton 2013)

Moderate consumption is acceptable during breastfeeding; it is advisable to monitor for signs of irritability, nervousness or insomnia in the infant.


See below the information of these related products:

  • Caffeine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Coffee (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Guarana in other languages or writings:

Group

Guarana belongs to this group or family:

Tradenames

Main tradenames from several countries containing Guarana in its composition:

  • 102 Plus™. Contains other elements than Guarana in its composition

References

  1. Moustakas D, Mezzio M, Rodriguez BR, Constable MA, Mulligan ME, Voura EB. Guarana provides additional stimulation over caffeine alone in the planarian model. PLoS One. 2015 Abstract Full text (link to original source)
  2. Ciszowski K, Biedroń W, Gomólka E. Acute caffeine poisoning resulting in atrial fibrillation after guarana extract overdose. Przegl Lek. 2014 Abstract
  3. EMA. Community herbal monograph on Paullinia cupana Kunth ex H.B.K. var. sorbilis (Mart.) Ducke, semen. Committee on Herbal Medicinal Products (HMPC). 2013 Full text (in our servers)
  4. Pendleton M, Brown S, Thomas CM, Odle B. Potential toxicity of caffeine when used as a dietary supplement for weight loss. J Diet Suppl. 2013 Abstract
  5. Schimpl FC, da Silva JF, Gonçalves JF, Mazzafera P. Guarana: revisiting a highly caffeinated plant from the Amazon. J Ethnopharmacol. 2013 Abstract
  6. Jalili J, Askeroglu U, Alleyne B, Guyuron B. Herbal products that may contribute to hypertension. Plast Reconstr Surg. 2013 Jan;131(1):168-173. Abstract
  7. Woods DJ. Guarana: Paullinia cupana, P. sorbilis; also known as Brazilian cocoa and 'zoom'. J Prim Health Care. 2012 Abstract
  8. Moaddeb J, Tofade TS, Bevins MB. Hypertensive Urgency Associated With Xenadrine EFX Use. J Pharm Pract. 2011 Jun 6. [Epub ahead of print] Abstract
  9. Arditti J, Bourdon JH, Spadari M, de Haro L, Richard N, Valli M. [Ma Huang, from dietary supplement to abuse]. Acta Clin Belg. 2002;57 Suppl 1:34-6. Review. French. Abstract

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