Last update Jan. 9, 2023

ガニレリクス酢酸塩

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Cetrorelix is a synthetic decapeptide antagonist of gonadorelin (gonadotropin-releasing hormone) that is used to prevent luteinizing hormone surges and premature ovulation in women undergoing ovarian stimulation treatment for assisted reproduction in cases of infertility. Subcutaneous administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its pharmacokinetic data (high percentage of protein binding, high molecular weight and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Its low oral bioavailability makes it difficult for it to pass to the infant’s plasma via ingested breast milk as, due to its protein nature, it degrades in the gastrointestinal tract and is not absorbed.


See below the information of this related product:

Alternatives

We do not have alternatives for ガニレリクス酢酸塩.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

ガニレリクス酢酸塩 is Ganirelix Acetate in Japanese.

Is written in other languages:

Group

ガニレリクス酢酸塩 belongs to this group or family:

Tradenames

Main tradenames from several countries containing ガニレリクス酢酸塩 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 1.691 daltons
Protein Binding 82 %
VD 0.6 l/Kg
pKa 9.5 -
Tmax 1 - 2 hours
T½ 13 - 16 hours

References

  1. Merck. Ganirelix. Drug Summary. 2018 Full text (in our servers)
  2. Ganirelix Ficha técnica 2013 Full text (in our servers)
  3. Ganirelix Drug Summary 2013 Full text (in our servers)
  4. EMA. Ganirelix. Ficha técnica, 2010 Full text (in our servers)
  5. Oberyé JJ, Mannaerts BM, Kleijn HJ, Timmer CJ. Pharmacokinetic and pharmacodynamic characteristics of ganirelix (Antagon/Orgalutran). Part I. Absolute bioavailability of 0.25 mg of ganirelix after a single subcutaneous injection in healthy female volunteers. Fertil Steril. 1999 Abstract

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