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It is an ultrashort-acting cardioselective β1-adrenergic blocker used for the treatment of supraventricular tachycardia and perioperative hypertension and/or tachycardia. There is some evidence that it reduces intraoperative and postoperative pain and opioid use (Gelineau 2018, Watts 2017). Intravenous administration.
At the date of the last update we did not find any published data on its excretion in breast milk.
Although its low protein binding can facilitate the passage into breast milk (Riant 1986), its high volume of distribution, its low lipid solubility and its very short half-life (9 minutes) make its excretion in breast milk very unlikely.
Its low oral bioavailability makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.