Last update Oct. 17, 2024

Ertugliflozin

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Ertugliflozin is a type 2 sodium-glucose cotransporter inhibitor. It has similar actions to dapagliflozin and is used as monotherapy or with other antidiabetic therapy, including insulin, in the treatment of type 2 diabetes mellitus. Oral administration as a once-daily dosage or twice-daily dosage if combined with metformin.

At the time of the last update, we found no published data on its excretion in breast milk.

Its pharmacokinetic data (large volume of distribution, moderately high molecular weight and very high percentage of binding to plasma proteins) make passage into breast milk in clinically significant quantities very unlikely.

Pending further published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.


See below the information of this related product:

  • Maternal Diabetes mellitus (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Acarbose (Safe product and/or breastfeeding is the best option.)
  • Glibenclamide (Safe product and/or breastfeeding is the best option.)
  • Glipizide (Safe product and/or breastfeeding is the best option.)
  • Hypocaloric Diet (Safe product and/or breastfeeding is the best option.)
  • Insulin (Safe product and/or breastfeeding is the best option.)
  • Maternal Sport (Safe product and/or breastfeeding is the best option.)
  • Metformin Hydrochloride (Safe product and/or breastfeeding is the best option.)
  • Miglitol (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ertugliflozin in other languages or writings:

Tradenames

Main tradenames from several countries containing Ertugliflozin in its composition:

  • Segluromet™. Contains other elements than Ertugliflozin in its composition
  • Steglatro
  • Steglujan™. Contains other elements than Ertugliflozin in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 - 100 %
Molecular weight 437 daltons
Protein Binding 93.9 %
VD 3.1 l/Kg
Tmax 1 hours
11 - 17 hours

References

  1. EMA. Ertugliflozina (Steglatro) Ficha técnica. 2022 Full text (link to original source)
  2. EMA. Ertugliflozin (Steglatro) Drug Summary. 2022 Full text (link to original source)

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