Last update March 29, 2022

ديسوجاسترال

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Desogestrel is a progestogen with a structure similar to levonorgestrel that is used as a contraceptive, alone or associated with an estrogen such as ethinyl estradiol. It is metabolized in the body to etonogestrel. Daily oral administration.

It is excreted in breast milk in clinically insignificant amounts (Bjarnadóttir 2001), with no harmful effects on breastfed infants from treated mother reported, except for two cases of transient gynecomastia (Bjarnadóttir 2001) and a case of scrotal hypertrichosis in a 4-month-old infant whose mother had also received treatment with another progestogen during pregnancy. (Janus 2013)

Desogestrel does not change the quantity or composition of milk, nor the growth and development of children followed up to 2.5 years. (Dutta 2013, Bjarnadóttir 2001)

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During lactation progestin-only contraceptives are preferable to those combined with estrogen and, in this case, those with a lower dose of estrogen. (CDC 2016, WHO/OMS 2015, Altshuler 2015, Berens 2015, CLM 2012, Moretti 2000)

For the first 4-6 weeks postpartum, non-hormonal methods are the first choice, followed by IUDs and progestogen implants. (Berens 2015, Mwalwanda 2013, Rowe 2013, CLM 2012)


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

ديسوجاسترال is Desogestrel in Arabic.

Is written in other languages:

Group

ديسوجاسترال belongs to this group or family:

Tradenames

Main tradenames from several countries containing ديسوجاسترال in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 (60 - 80) %
Molecular weight 311 daltons
Protein Binding 96 %
VD 1.5 l/Kg
pKa 13 -
Tmax 1.5 hours
30 hours
M/P ratio 0.6 -
Theoretical Dose 0.00001 -0.00005 mg/Kg/d
Relative Dose 1.2 - 3.7 %

References

  1. AEMPS. Desogestrel. Ficha técnica. 2020 Full text (in our servers)
  2. CDC - Curtis KM, Tepper NK, Jatlaoui TC, Berry-Bibee E, Horton LG, Zapata LB, Simmons KB, Pagano HP, Jamieson DJ, Whiteman MK. U.S. Medical Eligibility Criteria for Contraceptive Use, 2016. CDC - MMWR Recommendations & Reports. 2016 Abstract Full text (link to original source) Full text (in our servers)
  3. Berens P, Labbok M; Academy of Breastfeeding Medicine. Protocolo clínico de la ABM n.º 13: Anticoncepción durante la lactancia, revisado en 2015. Breastfeed Med. 2015 Full text (link to original source) Full text (in our servers)
  4. Berens P, Labbok M; Academy of Breastfeeding Medicine. ABM Clinical Protocol #13: Contraception During Breastfeeding, Revised 2015. Breastfeed Med. 2015 Abstract Full text (link to original source) Full text (in our servers)
  5. OMS. Criterios médicos de elegibilidad para el uso de anticonceptivos Quinta edición. Who Library. 2015 Full text (link to original source) Full text (in our servers)
  6. Altshuler AL, Gaffield ME, Kiarie JN. The WHO's medical eligibility criteria for contraceptive use: 20 years of global guidance. Curr Opin Obstet Gynecol. 2015 Abstract Full text (link to original source) Full text (in our servers)
  7. WHO. Department of Reproductive Health and Research World Health Organization. Medical eligibility criteria for contraceptive use: 20 years of global guidance. WHO/RHR/15.07. 2015 Abstract Full text (link to original source) Full text (in our servers)
  8. Dutta DK, Dutta I. Desogestrel mini pill: is this safe in lactating mother? J Indian Med Assoc. 2013 Abstract
  9. Mwalwanda CS, Black KI. Immediate post-partum initiation of intrauterine contraception and implants: a review of the safety and guidelines for use. Aust N Z J Obstet Gynaecol. 2013 Abstract
  10. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  11. Janus D, Wojcik M, Tyrawa K, Starzyk J. Transient isolated scrotal hair development in infancy. Clin Pediatr (Phila). 2013 Jul;52(7):628-32. Abstract
  12. CLM - Comité de Lactancia Materna de la AEP. Preguntas frecuentes sobre lactancia materna. Folleto. 2012 Full text (link to original source) Full text (in our servers)
  13. Bjarnadóttir RI, Gottfredsdóttir H, Sigurdardóttir K, Geirsson RT, Dieben TO. Comparative study of the effects of a progestogen-only pill containing desogestrel and an intrauterine contraceptive device in lactating women. BJOG. 2001 Abstract

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