Last update April 28, 2026

地诺孕素

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Dienogest is a progestogen structurally related to nortestosterone. It is used in the treatment of endometriosis and, associated with an estrogen, as a contraceptive. Oral administration.

A latest update no published data on excretion into breast milk were found.

Its pharmacokinetic data (high percentage of protein binding and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

For a detailed discussion with references:

  • on why non-hormonal methods are the first choice during the first 4–6 weeks postpartum, followed by IUDs and progestin implants,
  • on the potential problems associated with the use of combined estrogen-progestin contraceptives,
  • the possible decrease in milk production with estrogen use,
  • and why progestin-only contraceptives are preferable during breastfeeding,

see below: “(Combined Estrogen + Progestin Contraceptives, COCs)”


See below the information of these related products:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

地诺孕素 is Dienogest in Chinese.

Is written in other languages:

Group

地诺孕素 belongs to this group or family:

Tradenames

Main tradenames from several countries containing 地诺孕素 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 91 %
Molecular weight 311 daltons
Protein Binding 90 %
VD 0.55 l/Kg
pKa 13.78 -
Tmax 1.5 hours
T½ 10 - 14 hours

References

  1. AEMPS. Dienogest. Ficha técnica. 2015 Full text (in our servers)

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