Last update Dec. 4, 2020

D11AX08; H03AA04

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

A metabolite of thyroid hormones. It is used in cases of resistance to thyroid hormones.
Administered orally.

Since the last update we have not found published data on its excretion in breastmilk.

There is very little literature on this product and it is sold in very few countries.

It has been used in dieting products for slimming purposes, producing serious side effects such as impaired thyroid function, paralysis, diarrhea, fatigue, lethargy, excessive weight loss, galactorrhea, and heart and cerebrovascular problems (MedlinePlus 2019, Cohen 2011, Ma 2008, Scally 2003, Bauer 2002, Devoto 2001, Chow 1998), so its use is not indicated in general and less so during breastfeeding. Thyrotoxicosis has been reported after use in subcutaneous injections in mesotherapy (Danilovic 2008).

A low-calorie diet and moderate exercise are preferable. Many women who breastfeed regain their pre-pregnancy weight sooner than those who do not.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

D11AX08; H03AA04 is Tiratricol in ATC Code/s.

Is written in other languages:

D11AX08; H03AA04 is also known as

Groups

D11AX08; H03AA04 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing D11AX08; H03AA04 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 67 %
Molecular weight 622 daltons
VD 1.63 l/Kg
Tmax 0.7 hours
T½ 6 hours

References

  1. MedlinePlus. Fitoterapia y suplementos para bajar de peso. Información de salud para usted. 2019 Full text (link to original source) Full text (in our servers)
  2. MedlinePlus. Herbal remedies and supplements for weight loss. Trusted Health information for you 2019 Full text (link to original source) Full text (in our servers)
  3. Cohen-Lehman J, Charitou MM, Klein I. Tiratricol-induced periodic paralysis: a review of nutraceuticals affecting thyroid function. Endocr Pract. 2011 Jul-Aug;17(4):610-5. Abstract
  4. Danilovic DL, Bloise W, Knobel M, Marui S. Factitious thyrotoxicosis induced by mesotherapy: a case report. Thyroid. 2008 Jun;18(6):655-7. Abstract
  5. Ma RC, Chan MH, Poon WT, So WY, Chow CC. Thyroid dysfunction due to over-the-counter usage of tiratricol. Intern Med J. 2008 Jul;38(7):611-2. Abstract
  6. [No authors listed] Ephedrine and tiratricol: freshly prepared mixtures forbidden in France. Prescrire Int. 2004 Apr;13(70):58. No abstract available. Abstract
  7. Scally MC, Hodge A. A report of hypothyroidism induced by an over-the-counter fat loss supplement (Tiratricol). Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):112-6. Abstract
  8. Bauer BA, Elkin PL, Erickson D, Klee GG, Brennan MD. Symptomatic hyperthyroidism in a patient taking the dietary supplement tiratricol. Mayo Clin Proc. 2002 Jun;77(6):587-90. Abstract
  9. Devoto E, Aravena L. Efectos adversos del ácido 3,5,3´ Triyodotiroacético en el tratamiento de la obesidad. [Adverse effect of 3,5,3 triiodothyroacetic acid in the treatment of obesity]. Rev Med Chil. 2001 Jun;129(6):691-3. Spanish. No abstract available. Abstract
  10. Chow WS, Lam KS. An overweight woman with galactorrhoea. Postgrad Med J. 1998 Feb;74(868):121-2. No abstract available. Abstract
  11. Menegay C, Juge C, Burger AG. Pharmacokinetics of 3,5,3'-triiodothyroacetic acid and its effects on serum TSH levels. Acta Endocrinol (Copenh). 1989 Nov;121(5):651-8. Abstract

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