Last update July 11, 2017

Carbimazole

Compatible

Safe product and/or breastfeeding is the best option.

Pro-drug which is metabolized to methimazole that is equivalent to 60% of drug.

Excretion into breast milk is insignificant (Low 1979, Johansen 1972, Rylance 1987).
No adverse effects reported in breastfed infants (Rylance 1987).
Plasma levels in those infants were shown to be very low (Rylance 1987).

Daily dose up to 30 mg has shown to be safe for the infant (Lamberg 1984, Verd 1998, Bartalena 2005) at both short term (hormone serum level) and long term (psychomotor development).follow-up.

The American Academy of Pediatrics rates us as compatible with breastfeeding


See below the information of this related product:

  • Methimazole (Safe product and/or breastfeeding is the best option.)

Alternatives

We do not have alternatives for Carbimazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Carbimazole is also known as


Carbimazole in other languages or writings:

Group

Carbimazole belongs to this group or family:

Tradenames

Main tradenames from several countries containing Carbimazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 186 daltons
Protein Binding 0 %
Tmax 1 - 2 hours
T½ 3 - 6 hours
M/P ratio 0.3 - 0.9 -
Theoretical Dose 0.0065 - 0. 015 mg/Kg/d
Relative Dose 0.6 - 6 %
Ped.Relat.Dose 0.6 - 3 %

References

  1. Soussan C, Gouraud A, Portolan G, Jean-Pastor MJ, Pecriaux C, Montastruc JL, Damase-Michel C, Lacroix I. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014 Abstract
  2. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W; American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011 Abstract
  3. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W; American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum.. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011 Abstract Full text (link to original source) Full text (in our servers)
  4. Fumarola A, Di Fiore A, Dainelli M, Grani G, Carbotta G, Calvanese A. Therapy of hyperthyroidism in pregnancy and breastfeeding. Obstet Gynecol Surv. 2011 Abstract
  5. Azizi F, Amouzegar A. Management of hyperthyroidism during pregnancy and lactation. Eur J Endocrinol. 2011 Abstract Full text (link to original source) Full text (in our servers)
  6. Karras S, Tzotzas T, Kaltsas T, Krassas GE. Pharmacological treatment of hyperthyroidism during lactation: review of the literature and novel data. Pediatr Endocrinol Rev. 2010 Abstract
  7. Glatstein MM, Garcia-Bournissen F, Giglio N, Finkelstein Y, Koren G. Pharmacologic treatment of hyperthyroidism during lactation. Can Fam Physician. 2009 Abstract Full text (link to original source) Full text (in our servers)
  8. Karras S, Tzotzas T, Krassas GE. Antithyroid drugs used in the treatment of hyperthyroidism during breast feeding. An update and new perspectives. Hormones (Athens). 2009 Abstract Full text (link to original source) Full text (in our servers)
  9. Inoue M, Arata N, Koren G, Ito S. Hyperthyroidism during pregnancy. Can Fam Physician. 2009 Abstract Full text (link to original source) Full text (in our servers)
  10. Koren G, Soldin O. Therapeutic drug monitoring of antithyroid drugs in pregnancy: the knowledge gaps. Ther Drug Monit. 2006 Abstract Full text (link to original source) Full text (in our servers)
  11. Azizi F. Treatment of post-partum thyrotoxicosis. J Endocrinol Invest. 2006 Abstract
  12. Törnhage CJ, Grankvist K. Acquired neonatal thyroid disease due to TSH receptor antibodies in breast milk. J Pediatr Endocrinol Metab. 2006 Abstract
  13. Bartalena L, Tanda ML, Bogazzi F, Piantanida E, Lai A, Martino E. An update on the pharmacological management of hyperthyroidism due to Graves' disease. Expert Opin Pharmacother. 2005 Abstract Full text (link to original source) Full text (in our servers)
  14. Azizi F, Bahrainian M, Khamseh ME, Khoshniat M. Intellectual development and thyroid function in children who were breast-fed by thyrotoxic mothers taking methimazole. J Pediatr Endocrinol Metab. 2003 Abstract
  15. Azizi F. Thyroid function in breast-fed infants is not affected by methimazole-induced maternal hypothyroidism: results of a retrospective study. J Endocrinol Invest. 2003 Abstract
  16. Azizi F, Hedayati M. Thyroid function in breast-fed infants whose mothers take high doses of methimazole. J Endocrinol Invest. 2002 Abstract
  17. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  18. Azizi F, Khoshniat M, Bahrainian M, Hedayati M. Thyroid function and intellectual development of infants nursed by mothers taking methimazole. J Clin Endocrinol Metab. 2000 Abstract Full text (link to original source) Full text (in our servers)
  19. Verd S, Cardo E. Well-being of a baby breast fed by her mother on carbimazol treatment. J Hum Lact. 1998 Abstract
  20. Azizi F. Effect of methimazole treatment of maternal thyrotoxicosis on thyroid function in breast-feeding infants. J Pediatr. 1996 Abstract
  21. Cooper DS. Antithyroid drugs: to breast-feed or not to breast-feed. Am J Obstet Gynecol. 1987 Abstract
  22. Rylance GW, Woods CG, Donnelly MC, Oliver JS, Alexander WD. Carbimazole and breastfeeding. Lancet. 1987 Abstract
  23. Cooper DS, Bode HH, Nath B, Saxe V, Maloof F, Ridgway EC. Methimazole pharmacology in man: studies using a newly developed radioimmunoassay for methimazole. J Clin Endocrinol Metab. 1984 Abstract
  24. Lamberg BA, Ikonen E, Osterlund K, Teramo K, Pekonen F, Peltola J, Välimäki M. Antithyroid treatment of maternal hyperthyroidism during lactation. Clin Endocrinol (Oxf). 1984 Abstract
  25. Johansen K, Andersen AN, Kampmann JP, Mølholm Hansen JM, Mortensen HB. Excretion of methimazole in human milk. Eur J Clin Pharmacol. 1982 Abstract
  26. Kampmann JP, Hansen JM. Clinical pharmacokinetics of antithyroid drugs. Clin Pharmacokinet. 1981 Abstract
  27. Tegler L, Lindström B. Antithyroid drugs in milk. Lancet. 1980 Abstract
  28. Low LC, Lang J, Alexander WD. Excretion of carbimazole and propylthiouracil in breast milk. Lancet. 1979 Abstract

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