Last update Jan. 27, 2021

Carbenoxolone Sodium

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Glycyrrhizinic acid (Glycyrrhizin, root extract of licorice) derivate.
Topical use for the treatment of mouth ulcers.

Since the last update we have not found any published data on its excretion in breast milk.

The small dose and poor plasma uptake of most topical oral preparations make it very unlikely that significant amounts will pass into breast milk.
Systemic absorption of topical oral carbenoxolone is minimal (AEMPS 2009).

There are very few bibliographic references which are also very old, and it is marketed in few countries.

The systemic use in the treatment of peptic ulcer has been abandoned due to serious side effects. Carbenoxolone should not be ingested.

See below the information of these related products:

  • Enoxolone (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Liquorice ( Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.)


We do not have alternatives for Carbenoxolone Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Carbenoxolone Sodium in other languages or writings:


Main tradenames from several countries containing Carbenoxolone Sodium in its composition:


Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 615 daltons
pKa 4.04 -


  1. AEMPS. Carbenoxolona (Sanodin gel). Ficha técnica. 2009 Full text (in our servers)

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