C₃₈ H₆₀ O₁₈

Several glycosides (rebaudiosides A, B, C, D and E, stevioside and dulcoside) used as sugar substitutes are obtained from the leaves of the Stevia rebaudiana plant native to Paraguay. The various glycosides are metabolized to steviol ^{(Purkayastha 2016, Wheeler 2008)}. It is a non-caloric sweetener about 300 times sweeter than sucrose. ^{(Vargas 2012)}

It has been popularly used in South America for centuries and in Japan and China for decades. It is used in traditional medicine with no proven scientific data on its effect on arterial hypertension or hyperglycemia. ^{(Ulbricht 2010)}

Devoid of toxicity ^{(Gens 2003)} at the dose of one or two cups of infusion daily. Maximum steviol intake: 4 mg per kg of body weight per day. 

Steviol glycosides are neither genotoxic nor carcinogenic. ^{(Urban 2013).}

At the date of last update we found no published data on their excretion in breast milk. 

Given its lack of toxicity at the correct doses, moderate consumption would be compatible with breastfeeding.

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