Last update Aug. 18, 2023

Steviol glycoside


Safe substance and/or breastfeeding is the best option.

Several glycosides (rebaudiosides A, B, C, D and E, stevioside and dulcoside) used as sugar substitutes are obtained from the leaves of the Stevia rebaudiana plant native to Paraguay. The various glycosides are metabolized to steviol (Purkayastha 2016, Wheeler 2008). It is a non-caloric sweetener about 300 times sweeter than sucrose. (Vargas 2012)

It has been popularly used in South America for centuries and in Japan and China for decades. It is used in traditional medicine with no proven scientific data on its effect on arterial hypertension or hyperglycemia. (Ulbricht 2010)

Devoid of toxicity (Gens 2003) at the dose of one or two cups of infusion daily. Maximum steviol intake: 4 mg per kg of body weight per day. 

Steviol glycosides are neither genotoxic nor carcinogenic. (Urban 2013).

At the date of last update we found no published data on their excretion in breast milk. 

Given its lack of toxicity at the correct doses, moderate consumption would be compatible with breastfeeding.

Translated with (free version)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Steviol glycoside is also known as Stevioside. Here it is a list of alternative known names::

Steviol glycoside in other languages or writings:


Steviol glycoside belongs to these groups or families:


Main tradenames from several countries containing Steviol glycoside in its composition:


Variable Value Unit
Molecular weight 805 daltons
Tmax 8 - 12 hours
14 hours


  1. Purkayastha S, Markosyan A, Prakash I, Bhusari S, Pugh G Jr, Lynch B, Roberts A. Steviol glycosides in purified stevia leaf extract sharing the same metabolic fate. Regul Toxicol Pharmacol. 2016 Abstract
  2. MedlinePlus. Edulcorantes y sustitutos del azúcar. Información de salud para usted. 2015 Full text (link to original source) Full text (in our servers)
  3. MedlinePlus. Sweeteners - sugar substitutes Trusted Health Information for you. 2015 Full text (link to original source) Full text (in our servers)
  4. Urban JD, Carakostas MC, Brusick DJ. Steviol glycoside safety: is the genotoxicity database sufficient? Food Chem Toxicol. 2013 Abstract
  5. Posadzki P, Watson LK, Ernst E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med (Lond). 2013 Abstract Full text (link to original source)
  6. Vargas Corrales, Verónica. Elaboración de té aromático a base de plantas cedrón (aloysia citrodora) y toronjil (mellisa officinalis) procesado con stevia (stevia rebaudiana bertoni) endulzante natural, utilizando el método de deshidratación. Tesis doctoral. Universidad Técnica de Cotopaxi. 2012 Full text (link to original source) Full text (in our servers)
  7. Ulbricht C, Isaac R, Milkin T, Poole EA, Rusie E, Grimes Serrano JM, Weissner W, Windsor RC, Woods J. An evidence-based systematic review of stevia by the Natural Standard Research Collaboration. Cardiovasc Hematol Agents Med Chem. 2010 Abstract
  8. Wheeler A, Boileau AC, Winkler PC, Compton JC, Prakash I, Jiang X, Mandarino DA. Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. Food Chem Toxicol. 2008 Abstract
  9. Geuns JM. Stevioside. Phytochemistry. 2003 Abstract

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