Last update Jan. 20, 2022
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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C21H25N is Terbinafine in Molecular formula.
Is written in other languages:C21H25N belongs to these groups or families:
Main tradenames from several countries containing C21H25N in its composition:
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Antifungal indicated for fungal infections of the skin, scalp and nails.
ORAL ADMINISTRATION:
Pharmacokinetics data (low oral bioavailability, high volume of distribution and high protein-binding capacity) explains the scanty excretion into breast milk observed.
In addition, its low oral bioavailability (Novartis 2018) would make even more difficult any pass of this drug through ingested milk to the infant's blood, except in newborns or premature who would show a higher intestinal absorption. (Thieme 1986 in Lactmed)
Avoid using in prematures who are under treatment with caffeine or theophylline because terbinafine alters its metabolic degradation and increases plasma concentration. (Novartis 2016, Mactal 2001)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (LactMed, Hale, Butler 2014, Mactal 2001), especially during the neonatal period and in the event of prematurity.
TOPICAL ADMINISTRATION: Fully compatible with breastfeeding. (Leachman 2006)
Since topical absorption is less than 5 %, a significant excretion into breast milk after application on skin is not expected.
Do not use on the breast to prevent ingestion by the infant, otherwise apply after a feeding and wipe it out thoroughly with water before next feeding.
It is recommended to avoid using on the nipple creams, gels and other products intended for use on skin that may contain paraffin (mineral oil) in order to keep from absorption the infant. (Concin 2008, Noti 2003)