Last update Oct. 14, 2022



Safe substance and/or breastfeeding is the best option.

It is a carboxypenicillin used in the treatment of serious gram-negative infections, especially those due to Pseudomonas aeruginosa. Intravenous administration.

It is excreted into breastmilk in a clinically insignificant amount. (Matsuda 1984, von Kobyletzki 1983)

Its null oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Ito 1993).

Expert authors consider the use of this medication to be safe during breastfeeding. (LacMed, Briggs 2015)


We do not have alternatives for C15H14N2Na2O6S2 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C15H14N2Na2O6S2 is Ticarcillin Sodium; Ticarcillin Disodium in Molecular formula.

Is written in other languages:


C15H14N2Na2O6S2 belongs to this group or family:


Main tradenames from several countries containing C15H14N2Na2O6S2 in its composition:


Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 428 daltons
Protein Binding 54 %
pKa 3.09 -
Tmax 0.5 - 1 hours
1.1 hours
Theoretical Dose 0.3 - 0.38 mg/Kg/d
Relative Dose 0.36 - 0.46 %


  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  5. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987 Abstract
  6. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  7. von Kobyletzki D, Dalhoff A, Lindemeyer H, Primavesi CA. Ticarcillin serum and tissue concentrations in gynecology and obstetrics. Infection. 1983 May-Jun;11(3):144-9. Abstract

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