Last update July 21, 2017

Bone Marrow Donation

Compatible

Safe substance and/or breastfeeding is the best option.

General, epidural or local anesthesia, as well as pretreatment with stimulating factors granulocyte colony (G-CSF), which may require the procedure, are not considered contraindications to breastfeeding. Neither analgesics that may be needed after the procedure. A healthy nursing mother can be, if desired and illegible, a bone marrow donor.
The G-CSF obtained by recombinant technology is identical to the natural product, which is a natural component of breast milk.

Their very high molecular weight explains the insignificant or excretion into milk that has been observed with both lenograstim and filgrastim.

A low oral bioavailability makes difficult their appearance into plasma from the ingested breast milk as for their protein nature, both are degraded in the gastrointestinal tract, and not absorbed. Filgrastim is not absorbed, even during the neonatal period or by premature infants.

Stimulating factor granulocyte colony (G-CSF) have been used in premature newborns and for prevention and treatment of neonatal sepsis and necrotizing enterocolitis with no adverse effects having been observed.

The bovine G-CSF is found in the usual diet of meat eaters.


See below the information of these related products:

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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References

  1. Pessach I, Shimoni A, Nagler A. Granulocyte-colony stimulating factor for hematopoietic stem cell donation from healthy female donors during pregnancy and lactation: what do we know? Hum Reprod Update. 2013 Abstract Full text (link to original source) Full text (in our servers)
  2. Kaida K, Ikegame K, Fujioka T, Taniguchi Y, Inoue T, Hasei H, Tamaki H, Yoshihara S, Kawase I, Ogawa H. Kinetics of granulocyte colony-stimulating factor in the human milk of a nursing donor receiving treatment for mobilization of the peripheral blood stem cells. Acta Haematol. 2007 Abstract Full text (link to original source) Full text (in our servers)
  3. Canpolat FE, Yurdakök M, Korkmaz A, Yiğit S, Tekinalp G. Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study. J Pediatr Surg. 2006 Abstract
  4. Shibata H, Yamane T, Aoyama Y, Nakamae H, Hasegawa T, Sakamoto C, Terada Y, Koh G, Hino M. Excretion of granulocyte colony-stimulating factor into human breast milk. Acta Haematol. 2003 Abstract Full text (link to original source) Full text (in our servers)
  5. Calhoun DA, Maheshwari A, Christensen RD. Recombinant granulocyte colony-stimulating factor administered enterally to neonates is not absorbed. Pediatrics. 2003 Abstract
  6. Carr R, Modi N, Doré C. G-CSF and GM-CSF for treating or preventing neonatal infections. Cochrane Database Syst Rev. 2003 Abstract
  7. Bedford Russell AR, Emmerson AJ, Wilkinson N, Chant T, Sweet DG, Halliday HL, Holland B, Davies EG. A trial of recombinant human granulocyte colony stimulating factor for the treatment of very low birthweight infants with presumed sepsis and neutropenia. Arch Dis Child Fetal Neonatal Ed. 2001 Abstract Full text (link to original source) Full text (in our servers)
  8. Gillan ER, Christensen RD, Suen Y, Ellis R, van de Ven C, Cairo MS. A randomized, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor administration in newborn infants with presumed sepsis: significant induction of peripheral and bone marrow neutrophilia. Blood. 1994 Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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