Last update Feb. 26, 2025

Lenograstim

Compatible

Safe product and/or breastfeeding is the best option.

Glycosylated granulocyte colony stimulating factor (G-CSF) obtained by recombinant technology. It has similar action and uses to Filgrastim. The natural product is a natural component of amniotic fluid, colostrum and breast milk (Pistilli 2013, Calhoun 2003). Indicated in neutropenia secondary to neoplasms and in severe congenital neutropenia. Subcutaneous or intravenous administration.

Its very high molecular weight explains the negligible or no passage into breast milk observed for both filgrastim and lenograstim. (Pistilli 2013, Kaida 2007, Shibata 2003)

Its low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk since, due to its protein nature, it is degraded in the gastrointestinal tract, not being absorbed. Filgrastim is not absorbed even during the neonatal period and in premature infants. (Pistilli 2013, Calhoun 2003).

Filgrastim granulocyte colony stimulating factor has been used in neonates and preterm infants for preventive purposes and treatment of neonatal sepsis and necrotizing enterocolitis with no adverse effects observed. (Canpolat 2006, Carr 2003, Bedford 2001, Gillan 1994)

Bovine G-CSF is found in the regular diet of meat eaters.

Alternatives

We do not have alternatives for Lenograstim since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Lenograstim is also known as


Lenograstim in other languages or writings:

  • لينوغراستيم (Arabic)
  • Ленограстим (Cyrillic)
  • 来格司亭 (Chinese)
  • レノグラスチム (Japanese)
  • 133-[O-[O-(N-Acetyl-α-neuraminosyl)-(2→3)-[O-β-d-galactopyranosyl-(1→3)]-2-acetamido-2-deoxy-β-d-galactopyranosyl]-l-threonine)]colony-stimulating factor (human clone 1034) mixture with 133-[O-[O-(N-acetyl-α-neuraminosyl)-(2→6)-O-[O-(N-acetyl-α-neuraminosyl)-(2→3)-β-d-galactopyranosyl-(1→3)]-2-acetamido-2-deoxy-β-d-galactopyranosyl]-l-threonine]-colony-stimulating factor (human clone 1034) (Chemical name)
  • L03AA10 (ATC Code/s)

Group

Lenograstim belongs to this group or family:

Tradenames

Main tradenames from several countries containing Lenograstim in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 18.669 daltons
VD 0.0007 l/Kg
Tmax 6 hours
T½ 1 - 4 hours
Theoretical Dose 0.000013 mg/Kg/d
Relative Dose 0.013 %

References

  1. Pessach I, Shimoni A, Nagler A. Granulocyte-colony stimulating factor for hematopoietic stem cell donation from healthy female donors during pregnancy and lactation: what do we know? Hum Reprod Update. 2013 Abstract Full text (link to original source) Full text (in our servers)
  2. Pistilli B, Bellettini G, Giovannetti E, Codacci-Pisanelli G, Azim HA Jr, Benedetti G, Sarno MA, Peccatori FA. Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: how should we counsel cancer patients about breastfeeding? Cancer Treat Rev. 2013 May;39(3):207-11. Abstract
  3. AEMPS. Lenograstim. Ficha técnica. 2009 Full text (in our servers)
  4. Kaida K, Ikegame K, Fujioka T, Taniguchi Y, Inoue T, Hasei H, Tamaki H, Yoshihara S, Kawase I, Ogawa H. Kinetics of granulocyte colony-stimulating factor in the human milk of a nursing donor receiving treatment for mobilization of the peripheral blood stem cells. Acta Haematol. 2007 Abstract Full text (link to original source) Full text (in our servers)
  5. Canpolat FE, Yurdakök M, Korkmaz A, Yiğit S, Tekinalp G. Enteral granulocyte colony-stimulating factor for the treatment of mild (stage I) necrotizing enterocolitis: a placebo-controlled pilot study. J Pediatr Surg. 2006 Abstract
  6. Martino M, Console G, Irrera G, Callea I, Condemi A, Dattola A, Messina G, Pontari A, Pucci G, Furlò G, Bresolin G, Iacopino P, Morabito F. Harvesting peripheral blood progenitor cells from healthy donors: retrospective comparison of filgrastim and lenograstim. J Clin Apher. 2005 Abstract
  7. Calhoun DA, Maheshwari A, Christensen RD. Recombinant granulocyte colony-stimulating factor administered enterally to neonates is not absorbed. Pediatrics. 2003 Abstract
  8. Carr R, Modi N, Doré C. G-CSF and GM-CSF for treating or preventing neonatal infections. Cochrane Database Syst Rev. 2003 Abstract
  9. Shibata H, Yamane T, Aoyama Y, Nakamae H, Hasegawa T, Sakamoto C, Terada Y, Koh G, Hino M. Excretion of granulocyte colony-stimulating factor into human breast milk. Acta Haematol. 2003 Abstract Full text (link to original source) Full text (in our servers)
  10. Bedford Russell AR, Emmerson AJ, Wilkinson N, Chant T, Sweet DG, Halliday HL, Holland B, Davies EG. A trial of recombinant human granulocyte colony stimulating factor for the treatment of very low birthweight infants with presumed sepsis and neutropenia. Arch Dis Child Fetal Neonatal Ed. 2001 Abstract Full text (link to original source) Full text (in our servers)
  11. Gillan ER, Christensen RD, Suen Y, Ellis R, van de Ven C, Cairo MS. A randomized, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor administration in newborn infants with presumed sepsis: significant induction of peripheral and bone marrow neutrophilia. Blood. 1994 Abstract Full text (link to original source) Full text (in our servers)

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