Last update June 3, 2024

Azapropazone (Apazone)

Compatible

Safe substance and/or breastfeeding is the best option.

Azapropazone is a non-steroidal anti-inflammatory drug (NSAID), structurally related to phenylbutazone. It also has uricosuric properties. It has been used in the treatment of rheumatoid arthritis, ankylosing spondylitis and acute gout. Oral administration

It is excreted into breast milk in very small amount. (Bald 1990)

American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)

 

 

Alternatives

  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Naproxen (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Azapropazone (Apazone) in other languages or writings:

Group

Azapropazone (Apazone) belongs to this group or family:

Tradenames

Main tradenames from several countries containing Azapropazone (Apazone) in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 83 %
Molecular weight 300 daltons
Protein Binding 99 %
VD 0.17 l/Kg
Tmax 3 - 6 hours
T½ 13 - 14 hours
Theoretical Dose 0.2 (0.11 - 0.47) mg/Kg/d
Relative Dose 0.55 - 2.4 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Bald R, Bernbeck-Betthäuser EM, Spahn H, Mutschler E. Excretion of azapropazone in human breast milk. Eur J Clin Pharmacol. 1990 Abstract
  3. Breuing KH, Gilfrich HJ, Meinertz T, Jähnchen E. Pharmacokinetics of azapropazone following single oral and intravenous doses. Arzneimittelforschung. 1979 Abstract

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