Last update Dec. 22, 2021
Oral dosage twice daily.
Its very high percentage of plasma protein binding explains the small transfer to breast milk observed. (Reece-Stremtan 2017, Østensen 2007, Jamali 1982)
However, somnolence in 10% of breastfed infants has been reported. (Ito 1993).
A case of acute anemia due to hemorrhage by coagulation disturbance in an one week aged infant.(Fidalgo 1989)
Long-term use while breastfeeding (Davanzo 2014, Sachs 2013) or in case of newborn jaundice is not recommended because a competitive effect on liver metabolism has been shown. (Risser 2009, Janssen 2000)
Short-term (1 week) or sporadic use has a low risk. (Jamali 1982)
American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM