Last update May 13, 2018



Safe substance and/or breastfeeding is the best option.

An amino acid component of proteins.
Found in meat, fish, dairy products, nuts and seeds (AESAN 2012). It stimulates the production of nitric oxide (vasodilatory) and the release of insulin and growth hormone.

It is indicated in states of deficiencies due to states of high catabolism or a very protein deficient diet. Most of its attributed therapeutic properties are not well-proven (MedlinePlus 2012, AESAN 2012). It is used in diagnostic tests for growth hormone (Biomed 2009).

It is found naturally in breastmilk at a higher concentration in colostrum than in mature milk (Lawrence 2016 p.766, Bjelaković 2010).

Since the last update we have not found published data in relation to breastfeeding.

Although an excess of amino acids or proteins in the diet can increase plasma levels, the concentration of proteins and other components of the milk is regulated in the epithelial mammary cell and is very independent of the plasma concentrations.

It has been used to prevent necrotizing enterocolitis in premature infants (MedlinePlus2012, Lee 2011, Thompson 2008).

It has a high safety profile, with no adverse effects observed at the recommended doses. A maximum daily intake of up to 3g (AESAN 2012) is advised.

Its moderate and non-abusive consumption is probably harmless during breastfeeding. 


We do not have alternatives for Arginine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Arginine is also known as

Arginine in other languages or writings:


Variable Value Unit
Oral Bioavail. 20 %
Molecular weight 174 daltons
VD 0.26 - 0.47 l/Kg
Tmax 1.5 hours
0.25 - 0.5 hours


  1. AEMPS. Arginina (Potenciator). Ficha técnica. 2014 Full text (in our servers)
  2. MedlinePLus Arginine MedlinePlus Supplements. 2012 Full text (link to original source) Full text (in our servers)
  3. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  4. MedlinePlus. Arginina MedlinePlus Suplementos. 2012 Full text (link to original source) Full text (in our servers)
  5. Lee JH. An update on necrotizing enterocolitis: pathogenesis and preventive strategies. Korean J Pediatr. 2011 Abstract Full text (in our servers)
  6. Bjelaković L, Kocić G, Cvetković T, Stojanović D, Najmen S, Jevtovic T, Bjelaković B, Pop-Trajković Z, Bjelaković G. Arginase activity in human milk during the first month of lactation. J Basic Clin Physiol Pharmacol. 2010 Abstract
  7. Biomed Ltd. Arginine Data Sheet 2009 Full text (in our servers)
  8. Thompson AM, Bizzarro MJ. Necrotizing enterocolitis in newborns: pathogenesis, prevention and management. Drugs. 2008 Abstract
  9. van Haeften TW, Konings CH. Arginine pharmacokinetics in humans assessed with an enzymatic assay adapted to a centrifugal analyzer. Clin Chem. 1989 Abstract Full text (in our servers)

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