Last update April 15, 2024

Amlodipine

Compatible

Safe product and/or breastfeeding is the best option.

It is a dihydropyridine-type calcium channel blocker with actions similar to those of nifedipine. It is used in the treatment of hypertension and angina pectoris. Oral administration once daily.

It is excreted into breast milk in low (Aoki 2018, Naito 2015) or undetectable (Morgan 2018) concentration, without problems observed in infants whose mothers were on treatment with this drug. (Naito 2015, Szucs 2010, Ahn 2007)

When measured, the plasma levels of drug in these infants were undetectable. (Aoki 2018, Morgan 2018, Vasa 2013 S15-poster 29).

Because its drug elimination period is very prolonged, safer known alternatives may be preferable, especially during the neonatal period and in case of premature infant. However, the measurements, which have been undetectable, have been made in newborns, in the first week of life, and several of them were premature. (Aoki 2018)

Experts authors consider the use of this medication to be compatible during breastfeeding. (Lactmed, Hale, Ghelfi 2021, Briggs 2015)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Amlodipine is also known as


Amlodipine in other languages or writings:

Groups

Amlodipine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Amlodipine in its composition:

List of 88 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 - 65 %
Molecular weight 409 daltons
Protein Binding 93 - 98 %
VD 21 l/Kg
pKa 8.7 -
Tmax 6 - 12 hours
T½ 35 - 65 hours
M/P ratio 0.74 -
Theoretical Dose 0.0015 - 0.0042 mg/Kg/d
Relative Dose 4.2 (0.9 - 7.3) %
Ped.Relat.Dose 1.5 - 4.2 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Ghelfi AM, Ferretti MV, Staffieri GJ. Tratamiento farmacológico de la hipertensión arterial no severa durante el embarazo, el posparto y la lactancia. [Pharmacological treatment of non-severe hypertension during pregnancy, postpartum and breastfeeding]. Hipertens Riesgo Vasc. 2021 Feb 22. pii: S1889-1837(21)00013-1. Abstract
  3. Morgan JL, Kogutt BK, Meek C, Stehel EK, McIntire DD, Sheffield JS, Roberts SW. Pharmacokinetics of amlodipine besylate at delivery and during lactation. Pregnancy Hypertens. 2018 Jan;11:77-80. Abstract
  4. Aoki H, Ito N, Kaniwa N, Saito Y, Wada Y, Nakajima K, Sago H, Murashima A, Okamoto A, Ito S. Low Levels of Amlodipine in Breast Milk and Plasma. Breastfeed Med. 2018 Nov;13(9):622-626. Abstract
  5. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source)
  6. Naito T, Kubono N, Deguchi S, Sugihara M, Itoh H, Kanayama N, Kawakami J. Amlodipine passage into breast milk in lactating women with pregnancy-induced hypertension and its estimation of infant risk for breastfeeding. J Hum Lact. 2015 May;31(2):301-6. Abstract
  7. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  8. Amlodipine Data Sheet 2013 Full text (in our servers)
  9. Vasa R, Martha Ramirez M. Amlodipine exposure through breastfeeding in a 32 week preterm newborn. Breastfeeding Med. 2013;8 (Suppl 1):S15. Breastfeeding Med; 8 (Suppl 1):S15. 2013 Full text (link to original source) Full text (in our servers)
  10. Szucs KA, Axline SE, Rosenman MB. Maternal membranous glomerulonephritis and successful exclusive breastfeeding. Breastfeed Med. 2010 Jun;5(3):123-6. Abstract
  11. Amlodipino Ficha técnica 2007 Full text (in our servers)
  12. Ahn HK, Nava-Ocampo AA, Han JY, Choi JS, Chung JH, Yang JH, Koong MK, Park CT. Exposure to amlodipine in the first trimester of pregnancy and during breastfeeding. Hypertens Pregnancy. 2007;26(2):179-87. Abstract
  13. Meredith PA, Elliott HL. Clinical pharmacokinetics of amlodipine. Clin Pharmacokinet. 1992 Abstract

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