Last update Sept. 4, 2022

Alizapride Hydrochloride

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a prokinetic from the benzamide group, a dopamine antagonist and similar to metoclopramide (Humax 2008). It is used IV, IM and orally every 8 to 12 hours to prevent nausea and vomiting associated with medical and surgical procedures, and cancer therapies

Since the last update we have not found published data on its excretion in breastmilk.

The scarcity of known pharmacokinetic data does not allow to predict the magnitude of its possible excretion in breast milk.

Due to its chemical similarity to metoclopramide, its excretion in breastmilk could be minimal.

Due to its inhibitory effect on dopamine (DrugBank), milk production could increase due to an increase in prolactin. (Minapharm 2014, Humax 2008)

A product with very few bibliographical references and sold in very few countries.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Domperidone ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Metoclopramide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ondansetron ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Alizapride Hydrochloride in other languages or writings:

Groups

Alizapride Hydrochloride belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Alizapride Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 75 - 100 %
Molecular weight 315 daltons
VD 0.5 - 0.9 l/Kg
pKa 8.9 -
3 hours

References

  1. DRUGBANK ONLINE. DrugBank.com 2006 - Consulted on April 18, 2022 Full text (link to original source)
  2. Minapharm. Alizapride (Nausilex). Drug Summary. 2014 Full text (in our servers)
  3. Humax. Alizaprida. Ficha técnica. 2008 Full text (in our servers)
  4. Houin G, Barre J, Tillement JP. Absolute intramuscular, oral, and rectal bioavailability of alizapride. J Pharm Sci. 1984 Abstract

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