Last update June 29, 2020
Adefovir is a nucleotide reverse transcriptase inhibitor, structurally related to adenine, used for treatment of chronic hepatitis B. Usually a long-term treatment is required.
Oral administration once a day.
Since the last update we have not found any published data on its excretion in breast milk.
Its pharmacokinetic data (not very high molecular weight and low protein binding) makes transfer to milk possible in amounts that could be significant. its use during breastfeding is not recommended (Mahadevan 2006).
There is widespread agreement among medical associations and expert consensus that maternal hepatitis B is not transmitted to the infant through breastmilk and therefore does not contraindicate breastfeeding (Mammas 2017,Visvanathan 2016, Dionne 2016, Fouquet 2016, Sogni 2015).
Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.
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