Last update Dec. 30, 2021


Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Second generation antihistamine, derived from piperazine, with minimal sedative effects and very low toxicity even at high doses.

Since the last update we have not found published data on its excretion in breast milk, but it is an enantiomer and active metabolite of cetirizine, that It is excreted in breast milk in clinically insignificant amounts (Wilkerson 2021). No problems were detected in the short or long term in an infant whose mother took cetirizine during the first month after delivery as part of the treatment for pemphigus.(Westermann 2012)

Its high binding to plasma proteins makes its transfer to milk unlikely.

The British Society for Allergy and Clinical Immunology considers cetirizine safe during breastfeeding. (Powell 2007)

See below the information of this related product:


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

左西替利嗪 is Levocetirizine in Chinese.

Is written in other languages:

左西替利嗪 is also known as


左西替利嗪 belongs to this group or family:


Main tradenames from several countries containing 左西替利嗪 in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 389 daltons
Protein Binding 92 %
VD 0.4 l/Kg
Tmax 1 hours
8 - 12 hours


  1. Wilkerson H, Datta P, Rewers-Felkins K, Baker T, Hale TW. Maternal Transfer of Cetirizine Into Human Milk. J Hum Lact. 2021 Feb;37(1):135-138. Abstract
  2. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Feb;39(2):168-71. Abstract
  3. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007 Abstract Full text (link to original source) Full text (in our servers)
  4. del Cuvillo A, Mullol J, Bartra J, Dávila I, Jáuregui I, Montoro J, Sastre J, Valero AL. Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol. 2006;16 Suppl 1:3-12. Review. No abstract available. Abstract Full text (link to original source) Full text (in our servers)

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