Last update June 15, 2022

Ziprasidone

Compatible

Safe substance and/or breastfeeding is the best option.

An atypical or second generation antipsychotic indicated in the treatment of schizophrenia and manic episodes of bipolar disorder. Oral administration in two daily doses.

It is excreted in breast milk in trace or undetectable amounts. (Schlotterbeck 2009)

No problems were seen in a 6-month-old infant whose mother took ziprasidone during pregnancy and lactation. (Werremeyer 2009)

It can cause hyperprolactinemia and galactorrhoea. (Raza 2010. Saldaña 2007, Ramadan 2005, Kopecek 2005, Jordan 2003)

Expert authors consider this medication possible with caution during breastfeeding. (Hale, Uguz 2021), although other alternatives, such as olanzapine or quetiapine, may be preferable. (Hale, LactMed, Klinger 2013)


See below the information of this related product:

Alternatives

  • Olanzapine (Safe substance and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe substance and/or breastfeeding is the best option.)
  • Risperidone (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Ziprasidone is also known as


Ziprasidone in other languages or writings:

Groups

Ziprasidone belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Ziprasidone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 - 100 %
Molecular weight 413 daltons
Protein Binding 99 %
VD 1.5 l/Kg
pKa 12.2 -
Tmax 5 - 8; im: 1 hours
T½ 6 - 7; im: 2 - 5 hours
M/P ratio 0.06 -
Theoretical Dose < 0.0017 mg/Kg/d
Relative Dose < 0.3 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. Abstract
  4. Raza S, Haq F. Ziprasidone-induced galactorrhea in an adolescent female: a case report. Prim Care Companion J Clin Psychiatry. 2010;12(3). pii: PCC.09l00855. Abstract
  5. Schlotterbeck P, Saur R, Hiemke C, Gründer G, Vehren T, Kircher T, Leube D. Low concentration of ziprasidone in human milk: a case report. Int J Neuropsychopharmacol. 2009 Apr;12(3):437-8. Abstract
  6. Werremeyer A. Ziprasidone and citalopram use in pregnancy and lactation in a woman with psychotic depression. Am J Psychiatry. 2009 Abstract Full text (link to original source) Full text (in our servers)
  7. Saldaña SN, Delgado SV. Ziprasidone-associated galactorrhea in an adolescent female. J Child Adolesc Psychopharmacol. 2007 Apr;17(2):259-60. No abstract available. Abstract
  8. Kopecek M, Bares M, Mohr P. Ziprasidone-induced galactorrhea: a case report. Neuro Endocrinol Lett. 2005 Feb;26(1):69-70. Abstract
  9. Ramadan M, Khan A, Preskorn S. D2-blockade and possible ziprasidone-induced galactorrhea. Int Clin Psychopharmacol. 2005 Mar;20(2):113-4. Abstract
  10. Jordan MP. Ziprasidone-associated galactorrhea in a female teenager. J Am Acad Child Adolesc Psychiatry. 2003 Jan;42(1):4-5. No abstract available. Abstract

Total visits

4,397

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM