Last update July 19, 2023

Yellow Fever 17D Vaccine

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Live attenuated vaccine. Not indicated for infants younger than 6 months. It is considered to be safe for breastfed infants after 6-9 months of age.

Both wild-type and vaccine virus have been detected in some milk samples.

Several cases of YF vaccine-virus transmission to breastfed infants younger than 1 month who developed symptoms of meningo-encephalitis due to yellow fever virus after mother vaccination have been documented.

Mothers of infants older than 9 months who are traveling to endemic areas are recommended to be immunized with anti-yellow fever virus vaccine.

Traveling to endemic areas of infants younger than 9 months is not recommended because a higher risk of meningo-encephalitis due to vaccination. In case a travel should not be delayed, nursing mothers with children younger than 9 months are recommended to get vaccinated and pump and dump breast milk for 14 days, which is the period of active virus shedding after immunization. Mothers living in endemic areas are recommended to delay vaccination after the child is 6 months old. WHO Model List of Essential Drugs (2002): Compatible with breastfeeding

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Group

Yellow Fever 17D Vaccine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Yellow Fever 17D Vaccine in its composition:

References

  1. CDC- ACIP. Vaccine Recommendations and Guidelines of the ACIP. Special Situations. Breastfeeding and Vaccination. - 2023 Consulted on Oct. 25, 2023 Full text (link to original source)
  2. CDC - Centers for Disease Control and Prevention. Vaccination Safety for Breastfeeding Mothers. Breastfeeding and Special Circumstances. 2023 Full text (link to original source) Full text (in our servers)
  3. Hassan T, Bashir RA, Abdelrahman DN, Hassan Madni H, El Hussein ARM, Elkidir IM, Enan KA. Transmission of yellow fever vaccine virus from breast feeding mothers to their infants: reporting of yellow fever virus (YFV) RNA detection in milk specimens. F1000Research. 2022;11:76 Abstract Full text (link to original source)
  4. (Red Book). AAP. Kimberlin DW, Barnett ED, , Lynfield R, Sawyer MH eds. Red Book: 2021-2024. Report of the Committee on Infectious Diseases. 32th ed. Elk Grove Village, - 2021
  5. Ribeiro AF, Guedes BF, Sulleiman JMAH, de Oliveira FTM, de Souza IOM, Nogueira JS, Marcusso RMN, Fernandes EG, do Olival GS, de Figueiredo PHFM, Veiga APR, Dahy FE, Ximenes NN, Pinto LF, Vidal JE, de Oliveira ACP. Neurologic Disease after Yellow Fever Vaccination, São Paulo, Brazil, 2017-2018. Emerg Infect Dis. 2021 Jun;27(6). Abstract Full text (link to original source)
  6. Fernandes EG, Nogueira JS, Porto VBG, Sato HK. The search for yellow fever virus vaccine in breast milk of inadvertently vaccinated women in Brazil. Rev Inst Med Trop Sao Paulo. 2020;62:e33. Abstract Full text (link to original source)
  7. Ribeiro AF, Brasil LMCR, Prada RM, Nogueira JS, Maeda AY, Sztajnbok J. Detection of Wild-type Yellow Fever Virus in Breast Milk. Pediatr Infect Dis J. 2020 Jan;39(1):68-69. Abstract
  8. CAV-AEP. Comité asesor de vacunas de la Asociación Española de Pediatría. Lactancia materna y vacunas. None 2019 Full text (link to original source) Full text (in our servers)
  9. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  10. Raney EC, El-Ibiary SY. Immunizations and pregnancy: an update for pharmacists. J Am Pharm Assoc (2003). 2012 Abstract
  11. Thomas RE, Lorenzetti DL, Spragins W, Jackson D, Williamson T. The safety of yellow fever vaccine 17D or 17DD in children, pregnant women, HIV+ individuals, and older persons: systematic review. Am J Trop Med Hyg. 2012 Feb;86(2):359-72. Abstract Full text (link to original source)
  12. Traiber C, Coelho-Amaral P, Ritter VR, Winge A. Infant meningoencephalitis caused by yellow fever vaccine virus transmitted via breastmilk. J Pediatr (Rio J). 2011 Abstract
  13. Kuhn S, Twele-Montecinos L, MacDonald J, Webster P, Law B. Case report: probable transmission of vaccine strain of yellow fever virus to an infant via breast milk. CMAJ. 2011 Abstract Full text (in our servers)
  14. CDC. National Center for Immunization and Respiratory Diseases. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011 Abstract Full text (in our servers)
  15. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  16. Centers for Disease Control and Prevention (CDC). Transmission of yellow fever vaccine virus through breast-feeding - Brazil, 2009. MMWR Morb Mortal Wkly Rep. 2010 Abstract Full text (in our servers)
  17. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Yellow fever virus transmission via breastfeeding: follow-up to the paper on breastfeeding travelers. J Travel Med. 2010 Abstract Full text (in our servers)
  18. Staples JE, Gershman M, Fischer M; Centers for Disease Control and Prevention (CDC). Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2010 Abstract Full text (in our servers)
  19. Imbert P, Moulin F, Mornand P, Méchaï F, Rapp C. [Should yellow fever vaccination be recommended during pregnancy or breastfeeding?]. Med Trop (Mars). 2010 Abstract
  20. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  21. Pickering LK, Granoff DM, Erickson JR, Masor ML, Cordle CT, Schaller JP, Winship TR, Paule CL, Hilty MD. Modulation of the immune system by human milk and infant formula containing nucleotides. Pediatrics. 1998 Feb;101(2):242-9. Abstract
  22. Pabst HF, Spady DW, Pilarski LM, Carson MM, Beeler JA, Krezolek MP. Differential modulation of the immune response by breast- or formula-feeding of infants. Acta Paediatr. 1997 Abstract

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