Last update Sept. 6, 2022

Vitamin B1 Substances

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Thiamine or Vitamin B1 is a water soluble vitamin. In addition to Thiamine, other chemical compounds with similar activity: Acetiamine, Benfotiamine, Bisbentiamine, Bisbutiamina, Cetotiamina, Cicotiamina, Cocarboxylase, Fursultiamine, Monofosfotiamina, Octotiamine, Pyrophosphotiamine, Prosultiamine and Sulbutiamine. It is essential for the metabolism of carbohydrate nutrients.

Its deficiency causes severe neuromuscular and cardiac symptoms known as Beriberi and Wernicke-Korsakoff disease (Rao 2010). Thiamine deficiency is common among disadvantaged populations in Southeast Asia (predominantly consumers of refined rice), other malnourished people (refugees, low socioeconomic status ...) and chronic alcohol consumption (Butterworth 2001, McGready 2001, Doran 1997). Beriberi of childhood, both infants and children, may arise from breastfeeding by Thiamine deficient mothers (Moulin 2014, Coats 2013, Bowman 2013, Allen 2012, Debuse 1992). Reportedly, several severe cases have occured after feeding the babies with artificial formulas that were not supplemented with vitamin B1. (Shamir 2012, Fattal 2005, Siegel 2003)

Daily allowance is higher during pregnancy and lactation (1.5 mg / day) which is readily obtained through a varied diet with adequate content of whole grains, legumes, nuts, eggs and lean meat. (Ares 2015, Hall 2010)

Thiamine is excreted in breast milk and gradually increases with time, being lower in colostrum (28 ng / mL) and transitional milk than in mature milk (180 ng / mL) (Ford 1983). The concentration is lower in milk from mothers of preterm (90 ng / mL). (Ren 2015)

Taking vitamin supplementation is not required if diet and nutritional status are adequate(Ares 2015). Supplementation does not increase levels in milk of well-nourished women (Keikha 2021, Stuetz 2012, Thomas 1980), but of those with a low nutritional status. The supplementation of group B vitamins and C and E vitamins to HIV positive mothers improves the weight growth of their breasted babies.

There is no evidence of their effectiveness in improving athletic performance, lack of appetite, sores, stress, fatigue or aging.

Toxicity linked to excessive consumption of thiamine is not known.

Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002). American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)

Alternatives

We do not have alternatives for Vitamin B1 Substances since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Vitamin B1 Substances belongs to this group or family:

Tradenames

Main tradenames from several countries containing Vitamin B1 Substances in its composition:

  • 102 Plus™. Contains other elements than Vitamin B1 Substances in its composition
  • Adelgazar™. Contains other elements than Vitamin B1 Substances in its composition
  • Arcalion
  • Bago B1 B6 B12™. Contains other elements than Vitamin B1 Substances in its composition
  • Bedoyecta tri™. Contains other elements than Vitamin B1 Substances in its composition
  • Benerva
  • Dolo-Tiaminal™. Contains other elements than Vitamin B1 Substances in its composition
  • Elevit™. Contains other elements than Vitamin B1 Substances in its composition
  • Hidroxil B12 B6 B1™. Contains other elements than Vitamin B1 Substances in its composition
  • Inzitan™. Contains other elements than Vitamin B1 Substances in its composition
  • Megastene
  • Milgamma Mono
  • Multibionta Complex™. Contains other elements than Vitamin B1 Substances in its composition
  • Neurobion™. Contains other elements than Vitamin B1 Substances in its composition
  • Pazbronquial™. Contains other elements than Vitamin B1 Substances in its composition
  • Pharmaton Matruelle™. Contains other elements than Vitamin B1 Substances in its composition
  • Seidibion Embarazo™. Contains other elements than Vitamin B1 Substances in its composition
  • Seidibion Mater preparto, posparto y lactancia™. Contains other elements than Vitamin B1 Substances in its composition
  • Seidibion Prime Embarazo™. Contains other elements than Vitamin B1 Substances in its composition
  • Supradyn Forte™. Contains other elements than Vitamin B1 Substances in its composition
  • Supradyn Prenatal™. Contains other elements than Vitamin B1 Substances in its composition
  • Supradyn Pronatal™. Contains other elements than Vitamin B1 Substances in its composition
  • Surmenalit
  • Tiaminal B12™. Contains other elements than Vitamin B1 Substances in its composition
  • Tiaminal B12 Trivalente™. Contains other elements than Vitamin B1 Substances in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 5.3 %
Molecular weight 308 - 771 daltons
Tmax 1 hours
2.5 hours

References

  1. Keikha M, Shayan-Moghadam R, Bahreynian M, Kelishadi R. Nutritional supplements and mother's milk composition: a systematic review of interventional studies. Int Breastfeed J. 2021 Jan 4;16(1):1. Abstract Full text (link to original source)
  2. Ren X, Yang Z, Shao B, Yin SA, Yang X. B-Vitamin Levels in Human Milk among Different Lactation Stages and Areas in China. PLoS One. 2015 Abstract Full text (link to original source) Full text (in our servers)
  3. Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  4. Moulin P, Cinq-Frais C, Gangloff C, Peyre M, Seguela PE, Charpentier S, Cascarigny F, Alcouffe F, Periquet B, Dulac Y, Acar P. [Thiamine deficiency in infants: a case report]. Arch Pediatr. 2014 Abstract
  5. Coats D, Frank EL, Reid JM, Ou K, Chea M, Khin M, Preou C, Enders FT, Fischer PR, Topazian M. Thiamine pharmacokinetics in Cambodian mothers and their breastfed infants. Am J Clin Nutr. 2013 Abstract Full text (link to original source) Full text (in our servers)
  6. Bowman BA, Pfeiffer CM, Barfield WD. Thiamine deficiency, beriberi, and maternal and child health: why pharmacokinetics matter. Am J Clin Nutr. 2013 Abstract Full text (link to original source) Full text (in our servers)
  7. Stuetz W, Carrara VI, McGready R, Lee SJ, Biesalski HK, Nosten FH. Thiamine diphosphate in whole blood, thiamine and thiamine monophosphate in breast-milk in a refugee population. PLoS One. 2012 Abstract
  8. Allen LH. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr. 2012 Abstract Full text (link to original source) Full text (in our servers)
  9. Stuetz W, Carrara VI, McGready R, Lee SJ, Erhardt JG, Breuer J, Biesalski HK, Nosten FH. Micronutrient status in lactating mothers before and after introduction of fortified flour: cross-sectional surveys in Maela refugee camp. Eur J Nutr. 2012 Abstract Full text (link to original source) Full text (in our servers)
  10. Shamir R. Thiamine-deficient infant formula: what happened and what have we learned? Ann Nutr Metab. 2012 Abstract Full text (link to original source) Full text (in our servers)
  11. Rao SN, Chandak GR. Cardiac beriberi: often a missed diagnosis. J Trop Pediatr. 2010 Abstract
  12. Hall Moran V, Lowe N, Crossland N, Berti C, Cetin I, Hermoso M, Koletzko B, Dykes F. Nutritional requirements during lactation. Towards European alignment of reference values: the EURRECA network. Matern Child Nutr. 2010 Oct;6 Suppl 2:39-54. Abstract Full text (link to original source) Full text (in our servers)
  13. Fattal-Valevski A, Kesler A, Sela BA, Nitzan-Kaluski D, Rotstein M, Mesterman R, Toledano-Alhadef H, Stolovitch C, Hoffmann C, Globus O, Eshel G. Outbreak of life-threatening thiamine deficiency in infants in Israel caused by a defective soy-based formula. Pediatrics. 2005 Abstract
  14. Siegel-Itzkovich J. Police in Israel launch investigation into deaths of babies given formula milk. BMJ. 2003 Abstract Full text (link to original source) Full text (in our servers)
  15. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  16. Greer FR. Do breastfed infants need supplemental vitamins? Pediatr Clin North Am. 2001 Abstract
  17. Butterworth RF. Maternal thiamine deficiency: still a problem in some world communities. Am J Clin Nutr. 2001 Abstract Full text (link to original source)
  18. McGready R, Simpson JA, Cho T, Dubowitz L, Changbumrung S, Böhm V, Munger RG, Sauberlich HE, White NJ, Nosten F. Postpartum thiamine deficiency in a Karen displaced population. Am J Clin Nutr. 2001 Abstract Full text (link to original source)
  19. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  20. Doran L, Evers S. Energy and nutrient inadequacies in the diets of low-income women who breast-feed. J Am Diet Assoc. 1997 Abstract
  21. Loew D. Pharmacokinetics of thiamine derivatives especially of benfotiamine. Int J Clin Pharmacol Ther. 1996 Abstract
  22. Tallaksen CM, Sande A, Bøhmer T, Bell H, Karlsen J. Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orally. Eur J Clin Pharmacol. 1993 Abstract
  23. Debuse PJ. Shoshin beriberi in an infant of a thiamine-deficient mother. Acta Paediatr. 1992 Abstract
  24. Ford JE, Zechalko A, Murphy J, Brooke OG. Comparison of the B vitamin composition of milk from mothers of preterm and term babies. Arch Dis Child. 1983 Abstract Full text (link to original source) Full text (in our servers)
  25. Stolley H, Galgan V, Droese W. [Nutrient content in human milk: protein, lactose, minerals, trace elements, and thiamin (author's transl)]. Monatsschr Kinderheilkd. 1981 Abstract
  26. Nail PA, Thomas MR, Eakin R. The effect of thiamin and riboflavin supplementation on the level of those vitamins in human breast milk and urine. Am J Clin Nutr. 1980 Abstract
  27. Thomas MR, Sneed SM, Wei C, Nail PA, Wilson M, Sprinkle EE 3rd. The effects of vitamin C, vitamin B6, vitamin B12, folic acid, riboflavin, and thiamin on the breast milk and maternal status of well-nourished women at 6 months postpartum. Am J Clin Nutr. 1980 Abstract

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