Last update June 10, 2018

Vincamine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

This is one of the alkaloids from the Vinca minor plant with vasodilatory properties. Indicated without sufficient evidence to increase cerebral circulation.
Administered orally 3 times a day.

It can trigger serious cardiac arrhythmias (Fauchier 1993, Dany 1981).

It has very few bibliographical references. It is classified as having low therapeutic efficacy (Canary Islands Health Service 2011, INSALUD 2001).

Since the last update date we have not found published data on its excretion in breastmilk.

Until there is more published data about this drug in relation to breastfeeding, safer alternatives may be preferred, especially during the neonatal period and in the case of prematurity.

It is a non-essential medication and even more so during breastfeeding. If you have to use it, you can minimize the risk by waiting to breastfeed, if possible, about 4 hours after the medication is taken.

Alternatives

  • Pentoxifylline (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Vincamine in other languages or writings:

Group

Vincamine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Vincamine in its composition:

List of 7 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 355 daltons
Protein Binding 64 %
VD 2.9 l/Kg
Tmax 3 hours
T½ 0.9 hours

References

  1. DGF. Dirección General de Farmacia. Servicio Canario de la Salud. Listado de fármacos considerados de Utilidad terapéutica Baja (UTB). None 2011 Full text (in our servers)
  2. INSALUD. Área de Gestión de Farmacia. Subdirección General de Atención Primaria. Instituto Nacional de la Salud. Utilidad terapéutica de los medicamentos financiados por el Sistema Nacional de Salud. . 2001 Full text (in our servers)
  3. Fauchier JP, Fauchier L, Babuty D, Breuillac JC, Cosnay P, Rouesnel P. [Drug-induced ventricular tachycardia]. Arch Mal Coeur Vaiss. 1993 Abstract
  4. Dany F, Merle L, Goudoud JC, Liozon F, Blanc P, Bouvot JC, Nicot G, Dangoumau J. [Cardiac toxicity of vincamine: a seven cases report of ventricular arrhythmias by parenteral administration of vincamine (author's transl)]. Therapie. 1981 Abstract
  5. Lücker PW, Simon B, Talmont DM. [Pharmacokinetics of multilayer vincamine dragees. Study of normal subjects]. Arzneimittelforschung. 1978 Abstract

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