Last update July 1, 2015

Valaciclovir

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Precursor of Aciclovir which is used for treatment of infections due to Herpes zoster and Herpes simplex viruses and the prevention of Cytomegalovirus infection in immunocompromised patients.

It is excreted into breast milk as Aciclovir in non-significant clinical amount, with no side-effects observed among breastfed infants from treated mothers. Urine levels of Aciclovir in those infants were shown to be very low.

Alternatives

We do not have alternatives for Valaciclovir since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Valaciclovir is also known as


Valaciclovir in other languages or writings:

Group

Valaciclovir belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 54 %
Molecular weight 324 daltons
Protein Binding 15 %
Tmax 1 - 2 hours
T1/2 3 hours
M/P ratio 0,6 - 4 -
Theoretical Dose 0,023 - 1,5 mg/Kg/d
Relative Dose 0,05 - 8 %
Ped.Relat.Dose 0,004 - 2,5 %

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. GSK. Valacyclovir. Drug Summary 2013 Full text (in our servers)
  3. Drake AL, Roxby AC, Kiarie J, Richardson BA, Wald A, John-Stewart G, Farquhar C. Infant safety during and after maternal valacyclovir therapy in conjunction with antiretroviral HIV-1 prophylaxis in a randomized clinical trial. PLoS One. 2012 Abstract Full text (link to original source) Full text (in our servers)
  4. Drake AL, Roxby AC, Ongecha-Owuor F, Kiarie J, John-Stewart G, Wald A, Richardson BA, Hitti J, Overbaugh J, Emery S, Farquhar C. Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial. J Infect Dis. 2012 Abstract Full text (link to original source) Full text (in our servers)
  5. Valaciclovir. Ficha técnica. 2010 Full text (in our servers)
  6. Sheffield JS, Fish DN, Hollier LM, Cadematori S, Nobles BJ, Wendel GD Jr. Acyclovir concentrations in human breast milk after valaciclovir administration. Am J Obstet Gynecol. 2002 Abstract
  7. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract

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