Last update Dec. 2, 2022

Trospium Chloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Antimuscarinic with atropine-like effects. Indicated in the treatment of overactive bladder. Oral administration once or twice a day.

At the date of the last update, we did not find any published data on its excretion in breast milk.

Its large volume of distribution makes its passage to breast milk in a clinically significant amount unlikely.

Its low oral bioavailability (even lower if taken with food) hinders the transition to plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Milk production should be monitored, as there are reports (albeit few and old) that anticholinergics can reduce prolactin levels. (Masala 1982).


  • Oxybutynin (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Tolterodine Tartrate (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Trospium Chloride in other languages or writings:


Main tradenames from several countries containing Trospium Chloride in its composition:


Variable Value Unit
Oral Bioavail. 9.6 (4.0 - 16.1) %
Molecular weight 428 daltons
Protein Binding 50 - 85 %
VD 5.6 ± 2.0 l/Kg
pKa 11.05 -
Tmax 5.3 ± 1.2 hours
18.3 ± 3.2 hours


  1. AEMPS. Trospio. Ficha técnica. 2021 Full text (in our servers)
  2. Sunovion Ph. Trospium. Drug Summary. 2021 Full text (in our servers)
  3. Masala A, Alagna S, Devilla L, Rovasio PP, Rassa S, Faedda R, Satta A. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982 Jan-Feb;5(1):53-5. Abstract

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