Last update May 16, 2019

Tropicamide

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

An amine antimuscarinic with anticholinergic effects similar to atropine.
Indicated in occasional use to achieve mydriatic and/or cycloplegic effects in ophthalmic examinations.
Topical administration in the form of eye drops.

Since the last update we have not found any published data on its excretion in breast milk.

It reaches small plasma concentrations and its rapid elimination (AEMPS 2017, Vuori 1994) makes transfer into breastmilk in significant quantities very unlikely and, if you wish to minimize the already unlikely exposure, there should be a delay of two hours after administration before breastfeeding again.

The small dose and poor plasma absorption of most topical ophthalmic preparations make it unlikely that significant amounts will transfer into breastmilk.

Systemic absorption can be minimized by pressing on the tear duct (inner canthus of the eye) with a finger for 1-2 minutes (Bausch 2018).

Drugs with an anticholinergic/antimuscarinic effects can inhibit prolactin secretion (Masala 1982), but stimulation by infant suckling is usually sufficient to ensure the production of breastmilk (Messinis 1985).

Decreased production of breastmilk has not been reported with usual doses of antimuscarinic eye drops.

Alternatives

We do not have alternatives for Tropicamide.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Tropicamide is also known as


Tropicamide in other languages or writings:

Group

Tropicamide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tropicamide in its composition:

List of 16 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 284 daltons
Protein Binding 45 %
pKa 5.2 -
Tmax 0.1 - 0.5 hours
T½ < 0.25 hours

References

  1. Bausch. Tropicamide. Drug Summary. 2018 Full text (in our servers)
  2. AEMPS-Cusi. Tropicamida. Ficha técnica. 2017 Full text (in our servers)
  3. Vuori ML, Kaila T, Iisalo E, Saari KM. Systemic absorption and anticholinergic activity of topically applied tropicamide. J Ocul Pharmacol. 1994 Summer;10(2):431-7. Abstract
  4. Messinis IE, Souvatzoglou A, Fais N, Lolis D. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985 Apr;8(2):143-6. Abstract
  5. Masala A, Alagna S, Devilla L, Rovasio PP, Rassa S, Faedda R, Satta A. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982 Jan-Feb;5(1):53-5. Abstract

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