Last update Dec. 13, 2019

Trisodium Citrate

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Sodium salt of citric acid.
It is used rectally in enemas as it acts as an osmotic laxative and in bladder irrigations to dissolve clots. It has the alkalizing properties of urine, neutralizing gastric pH and is an anticoagulant.

Since the last update, we have not found published data on its excretion in breast milk.

Given the small amounts and route of administration, systemic absorption is practically nil (AEMPS 2013), so no significant excretion in breast milk is expected.

If absorbed, it is metabolized to bicarbonate, which is compatible with breastfeeding.

Both sodium and bicarbonate are normal components of the body and are found in breastmilk at concentrations which are different to plasma (Allen 1991).

See below the information of this related product:


We do not have alternatives for Trisodium Citrate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Trisodium Citrate is also known as Sodium Citrate.

Trisodium Citrate in other languages or writings:


Trisodium Citrate belongs to these groups or families:


Main tradenames from several countries containing Trisodium Citrate in its composition:

  • Clisteran™. Contains other elements than Trisodium Citrate in its composition
  • Micralax™. Contains other elements than Trisodium Citrate in its composition
  • Microlax ™. Contains other elements than Trisodium Citrate in its composition
  • Pazbronquial™. Contains other elements than Trisodium Citrate in its composition


Variable Value Unit
Molecular weight 294 daltons
VD 0,27 - 0,55 l/Kg
Tmax 1,6 - 2,2 hours
T1/2 0,3 - 0,9 hours


  1. AEMPS. Micralax. Ficha técnica. 2013 Full text (in our servers)
  2. Allen JC, Keller RP, Archer P, Neville MC. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr. 1991 Abstract

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