Last update Oct. 11, 2017

Triamcinolone Inhaled

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

A corticosteroid with a mainly glucocorticoid action and moderate anti-inflammatory effects (ATC D07AB), slightly higher than that of prednisolone (ATC D07AA).

Indicated inhaled use in the treatment of inflammatory diseases of the respiratory system: bronchitis, asthma, rhinitis, etc.

This comment is about inhaled triamcinolone.

Since the last update we have not found published data about its excretion in breast milk.

After inhaled administration, the bioavailability is 25% (Argenti 1999) and the plasma levels reached are clinically insignificant (Zaborny 1992).

There is consensus among experts that, in general, neither systemic corticoids nor inhaled ones present a breastfeeding contraindication (National Asthma Education 2004).

Corticoids are of commonally used in pediatrics and have no side effects when they are used in isolation or in short-term treatments.


See below the information of these related products:

Alternatives

We do not have alternatives for Triamcinolone Inhaled since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

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Triamcinolone Inhaled in other languages or writings:

Group

Triamcinolone Inhaled belongs to this group or family:

Tradenames

Main tradenames from several countries containing Triamcinolone Inhaled in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 - 30 %
Molecular weight 394 daltons
Protein Binding 68 %
VD 1.4 l/Kg
pKa 13.4 -
T½ 1.5 hours

References

  1. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  2. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  3. Argenti D, Shah B, Heald D. A pharmacokinetic study to evaluate the absolute bioavailability of triamcinolone acetonide following inhalation administration. J Clin Pharmacol. 1999 Abstract
  4. Zaborny BA, Lukacsko P, Barinov-Colligon I, Ziemniak JA. Inhaled corticosteroids in asthma: a dose-proportionality study with triamcinolone acetonide aerosol. J Clin Pharmacol. 1992 Abstract

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