Last update Aug. 23, 2021

Tirofiban Hydrochloride

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a non-peptide antagonist of the platelet surface receptor GP IIb/IIIa, preventing its binding with fibrinogen and blocking platelet aggregation.
Indicated in the prevention of myocardial infarction in acute coronary syndromes and in early percutaneous coronary intervention (PCI).
Administration by intravenous infusion for a maximum of 4-5 days.

At the date of the last update, there was no available published data on its excretion in breast milk.

Its pharmacokinetic data (large volume of distribution, moderately high molecular weight and short half-life) make it unlikely that it will pass into breast milk in a clinically significant quantity.

The risk can be minimized by waiting to breastfeed again between 6 and 8 hours after the last administration of the medicine.

The limitation to breastfeed will depend on the clinical situation of the mother.

Alternatives

We do not have alternatives for Tirofiban Hydrochloride.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tirofiban Hydrochloride in other languages or writings:

Group

Tirofiban Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tirofiban Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 495 daltons
Protein Binding 65 %
VD 0,3 -0,6 l/Kg
pKa 3,17 -
T1/2 1,4 - 2,2 hours

References

  1. AEMPS. Tirofiban. Ficha técnica. 2020 Full text (in our servers)
  2. Cipher Pharm. Tirofiban. Drug Summary. 2018 Full text (in our servers)

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