Last update Feb. 6, 2022

Thioacetazone

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Very low-cost bacteriostatic antituberculous drug, but less effective than other treatment regimens and with frequent severe skin reactions, which is why it is rarely used (Falzon 2014). Used alone or in combination with isoniazid. Daily oral administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

The paucity of known pharmacokinetic data does not allow prediction of its possible excretion in breast milk.

List of WHO essential medicines: compatible with breastfeeding. (WHO-UNICEF 2002)

Known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Thioacetazone is also known as


Thioacetazone in other languages or writings:

Group

Thioacetazone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Thioacetazone in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 236 daltons
pKa 11.71 -
Tmax 3 - 5 hours
T½ 12 - 15 hours

References

  1. Falzon D, Hill G, Pal SN, Suwankesawong W, Jaramillo E. Pharmacovigilance and tuberculosis: applying the lessons of thioacetazone. Bull World Health Organ. 2014 Dec 1;92(12):918-9. Abstract
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  3. Peloquin CA, Nitta AT, Berning SE, Iseman MD, James GT. Pharmacokinetic evaluation of thiacetazone. Pharmacotherapy. 1996 Sep-Oct;16(5):735-41. Abstract

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