Last update Oct. 14, 2022

The disodium salt of (6R)-6-(2-carboxy-2-phenylacetamido)penicillanic acid

Compatible

Safe substance and/or breastfeeding is the best option.

It is a carboxypenicillin that has been given by injection as the disodium salt, often with gentamicin, in the treatment of Pseudomonas aeruginosa infections. Other antipseudomonal penicillins such as ticarcillin or piperacillin are preferred.

It is excreted into breastmilk in a clinically insignificant amount. (Matsuda 1984)

Its poor oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Ito 1993).

Expert authors consider the use of this medication to be safe during breastfeeding. (LacMed, Briggs 2015)

Alternatives

We do not have alternatives for The disodium salt of (6R)-6-(2-carboxy-2-phenylacetamido)penicillanic acid since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

The disodium salt of (6R)-6-(2-carboxy-2-phenylacetamido)penicillanic acid is Carbenicillin Sodium; Carbenicillin Disodium in Chemical name.

Is written in other languages:

Group

The disodium salt of (6R)-6-(2-carboxy-2-phenylacetamido)penicillanic acid belongs to this group or family:

Tradenames

Main tradenames from several countries containing The disodium salt of (6R)-6-(2-carboxy-2-phenylacetamido)penicillanic acid in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 - 40 %
Molecular weight 422 daltons
Protein Binding 30 - 60 %
pKa 3.11 -
Tmax 3 hours
1 hours
M/P ratio 0.02 -
Theoretical Dose 0.015 - 0.036 mg/Kg/d
Relative Dose 0.1 - 0.2 %
Ped.Relat.Dose 0.01 -0.02 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract

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