Last update Feb. 11, 2019

Tetracosactide

Compatible

Safe product and/or breastfeeding is the best option.

The synthetic polypeptide tetracosactide has the same structure and properties as corticotropin, but only has the first 24 amino acids of its sequence, with a somewhat lower molecular weight.
Used as a diagnostic test for adrenocortical insufficiency in a single dose.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (high molecular weight and very short half-life) means it is very unlikely to transfer into breastmilk in significant amounts.

Because of its protein nature it is inactivated in the gastrointestinal tract, it is not absorbed, (practically zero oral bioavailability), which hinders or prevents transfer to infant plasma from breastmilk, except in premature births and the immediate neonatal period, when there may be increased intestinal permeability.

No harmful effects have been reported from the possible temporary increase of cortisol in plasma and breastmilk produced by the administration of ACTH.

Corticotropin may temporarily decrease prolactin levels (Hubina 2002) and prolactin may inhibit corticotropin secretion (Handlin 2009, Chiodera 1991), which should be taken into consideration in cases of breastfeeding.


See below the information of this related product:

  • Corticotropin (Safe product and/or breastfeeding is the best option.)

Alternatives

We do not have alternatives for Tetracosactide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Tetracosactide is also known as


Tetracosactide in other languages or writings:

Group

Tetracosactide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tetracosactide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 2.934 daltons
VD 0.4 l/Kg
T½ 0.12 - 0.25 hours

References

  1. Sigma-Tau. Tetracosactide (Synacthen). Drug Summary. 2014 Full text (in our servers)
  2. Handlin L, Jonas W, Petersson M, Ejdebäck M, Ransjö-Arvidson AB, Nissen E, Uvnäs-Moberg K. Effects of sucking and skin-to-skin contact on maternal ACTH and cortisol levels during the second day postpartum-influence of epidural analgesia and oxytocin in the perinatal period. Breastfeed Med. 2009 Abstract
  3. Hubina E, Nagy GM, Tóth BE, Iván G, Görömbey Z, Szabolcs I, Kovács L, Góth MI. Dexamethasone and adrenocorticotropin suppress prolactin secretion in humans. Endocrine. 2002 Abstract
  4. Chiodera P, Salvarani C, Bacchi-Modena A, Spallanzani R, Cigarini C, Alboni A, Gardini E, Coiro V. Relationship between plasma profiles of oxytocin and adrenocorticotropic hormone during suckling or breast stimulation in women. Horm Res. 1991 Abstract

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