Last update April 4, 2021


Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Heparin-like glycosaminoglycan which is a mixture of low molecular weight heparin (80%) and dermatan sulfate (20%) that has hypolipaemic and antithrombotic properties and used for treatment of venous insufficiency.
It does not have significant effects on coagulation but some protective properties on vascular endothelium is attributed.

At latest update on excretion into breast milk no published data were found.

Pharmacokinetic data (large volume of distribution and high molecular weight) make it unlikely the passage into milk in significant amounts.

Until more published data about this drug regarding breastfeeding is available, a safer alternative should be used, especially during the neonatal period and in case of prematurity.


  • Ethoxazorutoside ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Heparin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Hydrosmin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Rutoside ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Troxerutin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sulodexide in other languages or writings:


Sulodexide belongs to this group or family:


Main tradenames from several countries containing Sulodexide in its composition:


Variable Value Unit
Oral Bioavail. 40 (20 - 60) %
Molecular weight 6.500 (5.000 - 8.000) daltons
VD 1.0 ± 0.2 l/Kg
Tmax 1.33 ± 0.58 hours
11.7 - 25.8 hours


  1. AEMPS. Sulodexida. Ficha técnica. 2014 Full text (in our servers)
  2. Coccheri S, Mannello F. Development and use of sulodexide in vascular diseases: implications for treatment. Drug Des Devel Ther. 2013 Abstract
  3. Harenberg J. Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998 Abstract

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at

e-lactancia is a resource recommended by AELAMA of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM