Last update Sept. 1, 2022

Succinylcholine Chloride

Compatible

Safe substance and/or breastfeeding is the best option.

Succinylcholine or Suxamethonium is a muscle-relaxant agent with a peripheric depolarizing action that is used for rapid endotracheal intubation procedures, mechanical ventilation, and surgical procedures. Intravenous administration.

At latest update, no relevant published data concerning excretion into breast milk were found.

Because of a very rapid half-life elimination period, less than one minute (Kato 1999, Torda 1997, Hoshi 1993), a significant excretion into breast milk is unlikely. (Dalal 2014, Spigset 1994)

Also, its low oral bioavailability renders the pass of this agent to the infant's plasma highly unlikely. (Spigset 1994)

Succinylcholine should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in a good condition.

Experts authors consider the use of this medication to be probably compatible during breastfeeding (Briggs 2015, Dalal 2014, Howie 2006). Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

Alternatives

We do not have alternatives for Succinylcholine Chloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Succinylcholine Chloride is also known as


Succinylcholine Chloride in other languages or writings:

Group

Succinylcholine Chloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Succinylcholine Chloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 397 daltons
VD 0.0002 l/Kg
Tmax 0.01 hours
T½ 0.013 hours

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014 Abstract
  3. Howie WO, McMullen PC. Breastfeeding problems following anesthetic administration. J Perinat Educ. 2006 Abstract Full text (link to original source) Full text (in our servers)
  4. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  5. Kato M, Shiratori T, Yamamuro M, Haga S, Hoshi K, Matsukawa S, Jalal IM, Hashimoto Y. Comparison between in vivo and in vitro pharmacokinetics of succinylcholine in humans. J Anesth. 1999 Abstract
  6. Torda TA, Graham GG, Warwick NR, Donohue P. Pharmacokinetics and pharmacodynamics of suxamethonium. Anaesth Intensive Care. 1997 Abstract
  7. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994 Abstract
  8. Hoshi K, Hashimoto Y, Matsukawa S. Pharmacokinetics of succinylcholine in man. Tohoku J Exp Med. 1993 Abstract Full text (link to original source) Full text (in our servers)

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