Last update Nov. 22, 2022

Strontium-89

Incompatible

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Commentary.

It is a radiopharmaceutical agent used for the relief of bone pain in patients with painful skeletal metastases. Intravenous administration.

Plasma strontium and strontium accumulated in bones and other tissues of the mother is excreted in breast milk. (Shagina 2015, Tolstykh 2008, Harrison 2003)

The physical elimination half-life of strontium-89 is 50.5 days. After 10 physical half-lives the element ceases to have significant radioactivity.

Given its long elimination half-life, a 505-day cessation of breastfeeding would be required to avoid irradiating the infant, expressing and discarding the milk in the meantime, making it impossible to continue breastfeeding.

Alternatives

We do not have alternatives for Strontium-89.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Strontium-89 is also known as


Strontium-89 in other languages or writings:

Group

Strontium-89 belongs to this group or family:

Tradenames

Main tradenames from several countries containing Strontium-89 in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 160 daltons
Protein Binding 30 - 40 %
VD 0.57 - 0.96 l/Kg
Tmax 0.01 hours
T½ 1.200 hours

References

  1. Shagina NB, Tolstykh EI, Fell TP, Smith TJ, Harrison JD, Degteva MO. Strontium biokinetic model for the lactating woman and transfer to breast milk: application to Techa River studies. J Radiol Prot. 2015 Sep;35(3):677-94. Abstract
  2. Tolstykh EI, Shagina NB, Peremyslova LM, Degteva MO, Phipps AW, Harrison JD, Fell TP. Reconstruction of (90)Sr intake for breast-fed infants in the Techa riverside settlements. Radiat Environ Biophys. 2008 Jul;47(3):349-57. Abstract
  3. Harrison JD, Smith TJ, Phipps AW. Infant doses from the transfer of radionuclides in mothers' milk. Radiat Prot Dosimetry. 2003;105(1-4):251-6. Review. Abstract

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