Last update June 23, 2025

Spiramycin

Compatible

Safe product and/or breastfeeding is the best option.

It is a macrolide antibiotic used in bacterial infections in a similar way to erythromycin and in cryptosporidiosis and toxoplasmosis. Oral, intravenous or rectal administration in 2 to 3 daily doses.

At the date of the last update, we found no published data on its excretion in breast milk.

Its high molecular weight and large volume of distribution make excretion in breast milk in significant amounts unlikely.

Its low oral bioavailability, which is further reduced when taken with food, hinders its passage into the infant's plasma from ingested breast milk, except in premature infants and the immediate neonatal period, when there may be greater intestinal permeability.

It is a macrolide used in infants.

Expert authors recommend it during breastfeeding as an alternative to pyrimethamine and sulfadiazine. (Hacker 1998)

Until more published data on this drug in relation to breastfeeding is available, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.


See below the information of this related product:

Alternatives

  • Azithromycin (Safe product and/or breastfeeding is the best option.)
  • Clarithromycin (Safe product and/or breastfeeding is the best option.)
  • Pyrimethamine (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Spiramycin is also known as


Spiramycin in other languages or writings:

Group

Spiramycin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Spiramycin in its composition:

List of 22 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 - 40 %
Molecular weight 843 daltons
Protein Binding 10 - 30 %
VD 3.8 - 7.4 l/Kg
pKa 12.5 -
Tmax 0.5 - 4 hours
T½ 2 - 8 hours

References

  1. Hacker M, Richter R, Gümbel H, Richter T, Ohrloff C. [Toxoplasmosis retinochorioiditis, a therapy comparison between spiramycin and pyrimethamine/sulfadiazine]. Klin Monbl Augenheilkd. 1998 Abstract
  2. Brook I. Pharmacodynamics and pharmacokinetics of spiramycin and their clinical significance. Clin Pharmacokinet. 1998 Apr;34(4):303-10. Review. Abstract
  3. Periti P, Mazzei T, Mini E, Novelli A. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I). Clin Pharmacokinet. 1989 Abstract
  4. Frydman AM, Le Roux Y, Desnottes JF, Kaplan P, Djebbar F, Cournot A, Duchier J, Gaillot J. Pharmacokinetics of spiramycin in man. J Antimicrob Chemother. 1988 Jul;22 Suppl B:93-103. Abstract

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