Last update Feb. 15, 2016

Spiramycin

Compatible

Safe substance and/or breastfeeding is the best option.

It is assumed that excretion into breast milk achieves bacteriostatic concentrations.
A latest update no published data were found on excretion into breast milk.

Because a high molecular weight it seems unlikely an excretion into breast milk in significant amount.
A low oral bioavailability further reduced with simultaneous food intake impairs the appearance in the infant plasma from ingested milk except in preterm babies and those in the immediate neonatal period, which may have increased intestinal permeability.

Macrolide-based medication that is used in infants.
Until more published data on this drug regarding breastfeeding is available, safer alternatives with better known drugs should be preferable especially during the neonatal period and in case of prematurity..

Take into account the possible negative cultures in febrile infants whose mothers take antibiotics

Alternatives

  • Azithromycin (Safe substance and/or breastfeeding is the best option.)
  • Clarithromycin (Safe substance and/or breastfeeding is the best option.)
  • Pyrimethamine (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Spiramycin is also known as


Spiramycin in other languages or writings:

Group

Spiramycin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Spiramycin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 30 - 40 %
Molecular weight 843 daltons
Protein Binding 10 - 25 %
VD 3.8 - 7.4 l/Kg
Tmax 0.5 - 4 hours
T½ 2 - 8 hours

References

  1. Hacker M, Richter R, Gümbel H, Richter T, Ohrloff C. [Toxoplasmosis retinochorioiditis, a therapy comparison between spiramycin and pyrimethamine/sulfadiazine]. Klin Monbl Augenheilkd. 1998 Abstract
  2. Rubinstein E, Keller N. Spiramycin renaissance. J Antimicrob Chemother. 1998 Abstract Full text (link to original source) Full text (in our servers)
  3. Periti P, Mazzei T, Mini E, Novelli A. Clinical pharmacokinetic properties of the macrolide antibiotics. Effects of age and various pathophysiological states (Part I). Clin Pharmacokinet. 1989 Abstract
  4. Ziv G, Bogin E, Shani J, Sulman FG. Distribution and blood-to-milk transfer of labeled antibiotics. Antimicrob Agents Chemother. 1973 Abstract

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