Somatropin

Somatrem and somatropin are hormones of the anterior pituitary of recombinant DNA origin. They are large proteins, structurally similar to human growth hormone (hGH). Indicated in the treatment of short stature, hGH deficiency, short bowel syndrome and in the treatment of HIV-associated wasting or cachexia. Subcutaneous or intramuscular administration.

Its very high molecular weight explains the very small transfer to breast milk observed, in a clinically insignificant amount ^{(Breier1993, Milsom 1992)}. GH levels in milk do not increase after sc administration ^{(Breier1993, Milsom 1992)}. IGF- 1 levels in milk increases but the concentrations are 100 times lower than in plasma. ^{(Breier1993, Milsom 1992)}

No problems have been observed in infants whose mothers were treated with somatropin.^{(Milsom 1998, Gunn 1996, Milsom 1992)}

There was an increase in milk production in lactating mothers treated with somatropin. ^{(Gunn 1996, Breier1993, Milsom 1992)}

Somatotropin should not be used as a galactogogue due to limited published experience and possible side effects. ^{(Zuppa 2010, Gabay 2002)}

The best galactogogue is effective counseling during pregnancy and after childbirth to achieve frequent demand lactation and with correct technique in a mother who maintains her breastfeeding self-efficacy.^{(ACOG 2021, ABM-Brodribb 2018, Anderson 2013, Mannion 2012, Forinash 2012, ABM 2011, Seema 1997)}