Last update May 24, 2021

Sodium Thiosulphate

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Compuesto inorgánico que se utiliza en administración sistémica como antídoto en la intoxicación por cianuro y en extravasaciones de determinados antineoplásicos y, en aplicación tópica, como antifúngico.
Se ha utilizado en lactantes a partir del mes de edad.

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

Sus datos farmacocinéticos no permiten predecir su posible excreción en leche materna.

Su baja biodisponibilidad oral (Farese 2011) dificulta el paso a plasma del lactante a partir de la leche materna ingerida, salvo en prematuros y periodo neonatal inmediato en los que puede haber mayor permeabilidad intestinal.

Dada su corta vida media (Shea 1984) es posible volver a amamantar pasadas 6 horas de la última administración del medicamento si el estado clínico de la madre lo permite.

Listado de medicamentos esenciales OMS: la aplicación tópica dermatológica de tiosulfato de sodio es compatible con la lactancia (WHO 2002)

Alternatives

We do not have alternatives for Sodium Thiosulphate.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sodium Thiosulphate is also known as


Sodium Thiosulphate in other languages or writings:

Tradenames

Main tradenames from several countries containing Sodium Thiosulphate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 8 (1 - 26) %
Molecular weight 248 daltons
VD 0,15 l/Kg
pKa 11,35 -
T1/2 1,3 (0,3 – 2) hours

References

  1. Farese S, Stauffer E, Kalicki R, Hildebrandt T, Frey BM, Frey FJ, Uehlinger DE, Pasch A. Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers. Clin J Am Soc Nephrol. 2011 Jun;6(6):1447-55. Abstract
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  3. Shea M, Koziol JA, Howell SB. Kinetics of sodium thiosulfate, a cisplatin neutralizer. Clin Pharmacol Ther. 1984 Mar;35(3):419-25. Abstract

Total visits

3,905

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by IHAN of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM