Last update Jan. 10, 2024

Sodium Fluoride

Compatible

Safe substance and/or breastfeeding is the best option.

Sodium fluoride is an essential element for the development of bones and teeth.  It is used in oral or topical administration to prevent dental caries and intravenously in parenteral nutrition solutions. 

Fluoride is found in breast milk and there is little relationship of its concentration with the amount of fluoride ingested by the mother, the passage of fluoride from plasma to milk being limited (Campus 2014, Sever 2007, Koparal 2000, Opinya 1991, Spak 1983), which protects infants from a possible excess of fluoride ingested by the mother. (Valdez 2019, Opinya 1991)

WHO essential drug list: compatible with breastfeeding in doses used as a nutritional supplement. (WHO-UNICEF 2002)

Alternatives

We do not have alternatives for Sodium Fluoride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Sodium Fluoride in other languages or writings:

Groups

Sodium Fluoride belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Sodium Fluoride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 42 daltons
VD 0.5 - 0.7 l/Kg
pKa 3.17 -
Tmax 0.46 ± 0.17 hours
T½ 6 (3 - 10) hours
M/P ratio 0.3 -

References

  1. Valdez Jiménez L, Calderón Hernández J, Córdova Atilano RI, Sandoval Aguilar SY, Alegría Torres JA, Costilla Salazar R, Rocha Amador D. Dosis de exposición a fluoruros por el consumo de diferentes tipos de leche en residentes de una zona con hidrofluorosis endémica en México. [Level of exposure to fluorides by the consumption of different types of milk in residents from an area of Mexico with endemic hydrofluorosis]. An Pediatr (Engl Ed). 2019 Jun;90(6):342-348. Abstract Full text (link to original source)
  2. Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  3. Campus G, Congiu G, Cocco F, Sale S, Cagetti MG, Sanna G, Lingström P, Garcia-Godoy F. Fluoride content in breast milk after the use of fluoridated food supplement. A randomized clinical trial. Am J Dent. 2014 Aug;27(4):199-202. Abstract
  4. Sener Y, Tosun G, Kahvecioglu F, Gökalp A, Koç H. Fluoride levels of human plasma and breast milk. Eur J Dent. 2007 Jan;1(1):21-4. Abstract Full text (link to original source)
  5. EFSA. European Food Safety Authority. Tolerable upper intake levels for vitamins and minerals. Scientific Committee on Food. 2006 Full text (link to original source) Full text (in our servers)
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  7. Koparal E, Ertugrul F, Oztekin K. Fluoride levels in breast milk and infant foods. J Clin Pediatr Dent. 2000 Summer;24(4):299-302. Abstract
  8. Opinya GN, Bwibo N, Valderhaug J, Birkeland JM, Lökken P. Intake of fluoride and excretion in mothers' milk in a high fluoride (9 ppm) area in Kenya. Eur J Clin Nutr. 1991 Abstract
  9. Spak CJ, Hardell LI, De Chateau P. Fluoride in human milk. Acta Paediatr Scand. 1983 Sep;72(5):699-701. Abstract

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