Last update July 5, 2015

Secnidazole

Compatible

Safe substance and/or breastfeeding is the best option.

On last update relevant published data concerning breastfeeding were not found.

Pharmacokinetic data suggest that excretion into breast milk would be significant. However, it is considered safe for treatment of parasite infections like Amebiasis in children, with a dosage for children weighing over 5 kg that has been established by the manufacturer.

It is a medication included in a same group and similar properties of Metronidazole.

Alternatives

We do not have alternatives for Secnidazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Secnidazole in other languages or writings:

Groups

Secnidazole belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Secnidazole in its composition:

List of 46 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 185 daltons
Protein Binding 15 %
VD 7 l/Kg
Tmax 1 - 3 hours
T½ 25 - 30 hours

References

  1. Rodríguez Grullón JM, Castellanos Nouel M, Romero Suero Y, Rodríguez Caro R. Eficacia del Secnidazol a dosis única. Acta Médica Dominicana 31(1):23-26 2011 Full text (link to original source) Full text (in our servers)
  2. Aventis Pharma Secnidazol (Secnidal) Ficha técnica 2011 Full text (in our servers)
  3. Novag Secnidazol (Minovag) Ficha técnica 2011 Full text (in our servers)
  4. Goto R, Mascie-Taylor CG, Lunn PG. Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study. Trans R Soc Trop Med Hyg. 2009 Abstract
  5. Gillis JC, Wiseman LR. Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis. Drugs. 1996 Abstract
  6. Toppare MF, Kitapçi F, Senses DA, Yalcinkaya F, Kaya IS, Dilmen U. Ornidazole and secnidazole in the treatment of symptomatic intestinal amoebiasis in childhood. Trop Doct. 1994 Abstract
  7. Sinuhaji AB, Lubis CP, Daulay HR, Hamid ED, Lubis IT, Jufri A, Sutanto AH. A double blind trial between metronidazole and secnidazole in acute amebic dysentery in children (preliminary report). Paediatr Indones. 1986 Abstract

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