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Es un inhibidor selectivo irreversible de la monoamino oxidasa tipo B, una enzima involucrada en la degradación metabólica de la dopamina en el cerebro. Potencia los efectos de la levodopa y se usa en el tratamiento de la enfermedad de Parkinson como monoterapia inicial y como terapia adjunta a la levodopa. Administración oral una vez al día.
At the date of the last update we did not find any published data on its excretion in breast milk.
Its pharmacokinetic data (high percentage of protein binding and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.
By increasing the production of dopamine, it inhibits the secretion of prolactin and may decrease milk production, especially during the first weeks after delivery. After the first month and/or when lactation is well established, milk production does not depend as much on prolactin levels: the stimulation of the infant's suckling and regular emptying of the breast are usually sufficient to maintain lactation. (Messinis 1985)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.