Last update Jan. 3, 2023

Procyclidine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a tertiary amine with antimuscarinic and antispasmodic actions that is used for the symptomatic treatment of parkinsonism and drug-induced extrapyramidal dystonias. Oral or intravenous administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its pharmacokinetic data: very high percentage of protein binding (DrugBankl) and wide volume of distribution (Whiteman 1985), make it highly unlikely that significant quantities will pass into breast milk.

No changes in prolactin levels have been observed with the use of this medicine. (Johnstone 1983)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Biperiden (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Procyclidine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Procyclidine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 75 %
Molecular weight 287 daltons
Protein Binding 100 %
VD 1.1 l/Kg
pKa 13.84 -
12 hours

References

  1. DRUGBANK ONLINE. DrugBank.com 2006 - Consulted on Jan. 9, 2024 Full text (link to original source)
  2. Datapharm. Procyclidine Hydrochloride. https://www.medicines.org.uk/ 2023 Consulted on Jan. 3, 2023 Full text (link to original source)
  3. AEMPS. Prociclidina. Ficha técnica. 2019 Full text (in our servers)
  4. Whiteman PD, Fowle AS, Hamilton MJ, Peck AW, Bye A, Dean K, Webster A. Pharmacokinetics and Pharmacodynamics of procyclidine in man. Eur J Clin Pharmacol. 1985;28(1):73-8. Abstract
  5. Johnstone EC, Crow TJ, Ferrier IN, Frith CD, Owens DG, Bourne RC, Gamble SJ. Adverse effects of anticholinergic medication on positive schizophrenic symptoms. Psychol Med. 1983 Aug;13(3):513-27. Abstract

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