Last update Jan. 3, 2023


Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a tertiary amine with antimuscarinic and antispasmodic actions that is used for the symptomatic treatment of parkinsonism and drug-induced extrapyramidal dystonias. Oral or intravenous administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its pharmacokinetic data: very high percentage of protein binding (DrugBankl) and wide volume of distribution (Whiteman 1985), make it highly unlikely that significant quantities will pass into breast milk.

No changes in prolactin levels have been observed with the use of this medicine. (Johnstone 1983)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


  • Biperiden (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Procyclidine belongs to this group or family:


Main tradenames from several countries containing Procyclidine in its composition:


Variable Value Unit
Oral Bioavail. 75 %
Molecular weight 287 daltons
Protein Binding 100 %
VD 1.1 l/Kg
pKa 13.84 -
12 hours


  1. DRUGBANK ONLINE. 2006 - Consulted on Feb. 16, 2023 Full text (link to original source)
  2. Datapharm. Procyclidine Hydrochloride. 2023 Consulted on Jan. 3, 2023 Full text (link to original source)
  3. AEMPS. Prociclidina. Ficha técnica. 2019 Full text (in our servers)
  4. Whiteman PD, Fowle AS, Hamilton MJ, Peck AW, Bye A, Dean K, Webster A. Pharmacokinetics and Pharmacodynamics of procyclidine in man. Eur J Clin Pharmacol. 1985;28(1):73-8. Abstract
  5. Johnstone EC, Crow TJ, Ferrier IN, Frith CD, Owens DG, Bourne RC, Gamble SJ. Adverse effects of anticholinergic medication on positive schizophrenic symptoms. Psychol Med. 1983 Aug;13(3):513-27. Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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