Last update Jan. 30, 2021

Pivampicillin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Pivampicillin is an ester of ampicillin and has similar uses.It is an inactive pro-drug, which is converted during its gastrointestinal absorption to the active ampicillin.
Oral administration 3 or 4 times daily.
Authorized for use in infants.

It is excreted in breast milk in small amounts (Matheson 1988, Branebjerg 1987), much lower than the dose used for newborns and infants.

The possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account (Briggs 2017, Ito 1993).

Ampicillin, the active drug of pivampicillin, is compatible with breastfeeding.


See below the information of this related product:

  • Ampicilline ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Alternatives

We do not have alternatives for Pivampicillin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Pivampicillin is also known as


Pivampicillin in other languages or writings:

Group

Pivampicillin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Pivampicillin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 464 daltons
Protein Binding 15 %
pKa 11.7 -
Tmax 1.5 hours
0.8 - 1 hours
M/P ratio 0.01 - 0.6 -
Theoretical Dose 0.01 - 0.03 mg/Kg/d
Relative Dose 0.06 - 0.17 %

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Matheson I, Samseth M, Sande HA. Ampicillin in breast milk during puerperal infections. Eur J Clin Pharmacol. 1988;34(6):657-9. Abstract
  4. Branebjerg PE, Heisterberg L. Blood and milk concentrations of ampicillin in mothers treated with pivampicillin and in their infants. J Perinat Med. 1987;15(6):555-8. Abstract
  5. Ehrnebo M, Nilsson SO, Boréus LO. Pharmacokinetics of ampicillin and its prodrugs bacampicillin and pivampicillin in man. J Pharmacokinet Biopharm. 1979 Oct;7(5):429-51. Abstract

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